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Journal of Advances in Medicine and Medical Research, ISSN: 2456-8899, ISSN: 2231-0614 (Past),Vol.: 25, Issue.: 4


In-hospital Imaging Prevalence, Patterns of Neurological Involvement in Cerebral Venous Sinus Thrombosis: Analysis from Pakistan


Fatima Mubarak1, Muhammad Azeemuddin1, Shayan Sirat Maheen Anwar1, Waseem Mehmood Nizamani1 and Madiha Beg1*

1Department of Radiology, The Aga Khan University Hospital, Stadium Road, Karachi 75800, Pakistan.

Article Information


(1) Jera Kruja, Neurology, University of Medicine, Tirana, Albania and Member of Scientific Committee, European Academy of Neurology Member of Teaching Courses Committee, World Federation of Neurology, Albania.


(1) Adrià Arboix, University of Barcelona, Spain.

(2) Luis Rafael Moscote-Salazar, Universidad de Cartagena, Colombia.

(3) Predrag Džodić, University of Niš, Serbia.

Complete Peer review History:


Objective: The objective of the study was to calculate in-hospital imaging prevalence and report patterns of neurological involvement in cerebral venous sinus thrombosis patients presenting at a tertiary care hospital in a developing country.

Methods: A cross-sectional analytical study elicited data from the Department of Radiology at the Aga Khan University Hospital from January 2007 until December 2012. Patients of either sex were retrospectively recruited from medical record database. They were included if they presented with or were referred from clinical departments for evaluation of suspected cerebral venous sinus thrombosis. Diagnosis of cerebral venous sinus thrombosis was made on the basis of a combination of Magnetic resonance imaging with Magnetic resonance venogram imaging findings.

Results: A total of 597 scans were reviewed. Mean age was 37.46 ± SD 15.4 years, range: 72 years. Out of the total sample of 66, 28(46%) were males. Infarcts were more pronounced in females. Regarding clinical features, most commonly presenting symptom was a headache and weakness, 16 (26%) and 14 (23%) respectively. The 6 -year in-hospital imaging prevalence of cerebral venous sinus thrombosis was calculated as 11.055%, (66/597), 95% CI [8.54-13.56%] and true positive rate as 10.22%, (61/597), 95%CI [7.79-12.65%]). Patterns of sinus involvement were multi sinus involvement, and the major combination was superior sagittal, sigmoid and transverse 9(15%), sigmoid and transverse 8(13%), all sinuses 5 (8.2%).

Conclusion: There is increasing trend of multi sinus involvement in our population which can be detected early, by contrast, enhanced magnetic resonance venogram.

Keywords :

Prevalence; cerebral thrombosis; neurological disorder; magnetic resonance imaging; confidence interval; Pakistan.

Full Article - PDF    Page 1-9

DOI : 10.9734/JAMMR/2018/38540

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