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Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 23, Issue.: 6


Periodontitis: A Cellular Tactic to Escape Cancer


Luay Thanoon Younis1*, Mohamed Ibrahim Abu Hassan1 and Tara Bai Taiyeb Ali2

1Centre of Studies for Preclinical Sciences, Faculty of Dentistry, University of Technology MARA, Sungai Buloh 47000, Malaysia.

2Faculty of Dentistry, MAHSA University, Jenjarom 42610, Malaysia.

Article Information


(1) Ibrahim Farah, Professor, Jackson State University, Mississippi, USA.

(2) George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.


(1) Sara Bernardi, University of L’Aquila, Italy.

(2) Mehmet Yaltirik, Oral Surgery Istanbul Universty, Turkey.

(3) José Francisco Gómez Clavel, National Autonomous University of Mexico, México.

(4) Asha Ramesh, Saveetha University, India.

Complete Peer review History: http://www.sciencedomain.org/review-history/23069


During acute inflammation of gingiva (gingivitis), the cells can resist apoptosis and, at the same time, serve as a barrier to tumour formation. However, during chronic inflammation (periodontitis), the cells will undergo degradation which also helps in tumour restraining. Unlike the cellular senescence during cancer, periodontal cells undergo a unique senescence activity due to the microbial infection from the dental biofilm. The distinctive senescence activity of the inflamed periodontal cells results in the cell cycle arrest which leads to an inevitable degradation of periodontal tissues superpose the regeneration of them. If this activity is not resolved, continuous destruction of the supporting periodontal tissues may eventually result in the loss of teeth. In this mini-review, we discussed briefly the cellular senescence and its sequelae in periodontitis and cancer.

Keywords :

Periodontitis; senescence; apoptosis; cancer.

Full Article - PDF    Page 1-5

DOI : 10.9734/ARRB/2018/38291

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