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Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 23, Issue.: 4

Original-research-article

Postmortem Diagnosis of Induced Fatal Anaphylactic Shock in Rats

 

Said Said Elshama1,2*, Rasha R. Salem3, Hosam-Eldin Hussein Osman4,5 and Ayman El-Meghawry El-Kenawy6,7

1Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Taif University, Taif, Saudi Arabia.  

2Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia City, Egypt.

3Department of Anatomy, Faculty of Medicine, Alexandria University, Egypt.

4Department of Anatomy, College of Medicine, Taif University, Taif, Saudi Arabia.

5Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

6Department of Pathology, College of Medicine, Taif University, Taif, Saudi Arabia.

7Department of Molecular Biology, GEBRI, University of Sadat City, Sadat City, Cairo, Egypt.

Article Information

Editor(s):

(1) George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.

Reviewers:

(1) Samuel Ifedioranma Ogenyi, Nnamdi Azikiwe University, Nigeria.

(2) Diana C. Tapia-Pancardo, National Autonomous University of México, México.

(3) Rohan Ruwanpura, Karapitiya Teaching Hospital, Sri Lanka.

Complete Peer review History: http://www.sciencedomain.org/review-history/23020

Abstracts

Anaphylactic shock is a sudden and serious life-threatening systemic hypersensitivity leading to a rapid, irreversible fatal circulatory collapse. Postmortem diagnosis of fatal anaphylaxis is a very sophisticated task in forensic medicine; it is usually excluded as the cause of death due to lack of autopsy findings. This study aims to find more specific criteria for the postmortem diagnosis of induced fatal anaphylaxis in rats by assessing the levels of total tryptase, histamine, immunoglobulin E (IgE) and histological changes in the larynx, trachea, lung, heart, and spleen using light and electron microscopes. Sixty adult albino rats were divided into three groups; each group consisted of twenty rats. The first (control) group received distilled water while the second and third groups received a single intravenous dose of ovalbumin and penicillin G, respectively, two weeks after active subcutaneous sensitization. The fatal anaphylactic shock led to a significant increase in the levels of total tryptase, histamine and immunoglobulin E (IgE) along with histological changes in the larynx, trachea, lung, heart, and spleen that vary its severity according to the anaphylaxis cause. Postmortem diagnosis of fatal anaphylaxis depends on multi- factorial criteria that include biochemical, immunological and histological findings.

Keywords :

Diagnosis; anaphylaxis; postmortem.

Full Article - PDF    Page 1-14

DOI : 10.9734/ARRB/2018/39315

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