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Microbiology Research Journal International, 2456-7043,Vol.: 22, Issue.: 4

Short Communication

The Fallacy of Identification by Neutralization in the Light of Non-Cytopathic Effect Producing Enterovirus Strains


Moses Olubusuyi Adewumi1, Temitope Oluwasegun Cephas Faleye1,2  and Johnson Adekunle Adeniji1,3*

1Department of Virology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

2Department of Microbiology, Faculty of Science, Ekiti State University, Ado Ekiti, Ekiti State, Nigeria.

3WHO National Polio Laboratory, University of Ibadan, Ibadan, Oyo State, Nigeria.

Article Information
(1) Joao Lucio Azevedo, Professor, Department of Genetics, University of Sao Paulo, Escola Superior de Agricultura "Luiz de Queiroz" (ESALQ / USP), Sao Paulo, Brazil.
(1) J. A. A. S. Jayaweera, Rajarata University of Sri Lanka, Sri Lanka.
(2) Fellah Mamoun, Abbes Laghrour University, Algeria.
(3) El-Yuguda Abdul-Dahiru, University of Maiduguri, Nigeria.
Complete Peer review History: http://www.sciencedomain.org/review-history/22720


We describe the characterization of an enterovirus isolate recovered from untreated raw sewage in Ibadan, southwest Nigeria in 2010. The isolate was neutralized by specific antisera and consequently identified as Echovirus 7 (E7). Subsequent molecular characterization showed the isolate to be a mixture of E7 and Coxsackievirus A24 (CV-A24) thereby suggesting the CV-A24 strain to be non-cytopathic effect producing. It is therefore crucial that identities of enterovirus strains determined by neutralization assay be verified by molecular characterization to ensure they do not have any non-cytopathic effect producing strain(s) lurking unnoticed.

Keywords :

Nigeria; enterovirus; neutralization; Coxsackie Virus-A24; cytopathic effect.

Full Article - PDF    Page 1-6

DOI : 10.9734/MRJI/2017/38280

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