International Research Journal of Pure and Applied Chemistry, ISSN: 2231-3443,Vol.: 4, Issue.: 1 (January-February)
Cyclic Voltammetric Study of Losartan Potassium
S. Azhar Ali1 and Atya Hassan2* 1Department of Chemistry, University of Karachi, Karachi, Pakistan 7520. Pakistan.
2Federal Urdu University of Arts, Science and Technology, Gulshan Iqbal Campus Karachi,
S. Azhar Ali1 and Atya Hassan2*
1Department of Chemistry, University of Karachi, Karachi, Pakistan 7520. Pakistan.
(1) Enrico Franceschi, Department of Chemistry and Industrial Chemistry - University of Genoa Via Dodecanese 31-16146 Genoa, Italy.
(2) Monica Butnariu, Chemistry & Biochemistry Discipline, Banat’s University of Agricultural Sciences and Veterinary Medicine from Timisoara, 300645, Calea Aradului 119, Timis, Romania.
(3) Bengi Uslu, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
(4) Ichiro Imae, Division of Chemistry and Chemical Engineering, Faculty of Engineering, Hiroshima University, Japan.
Complete Peer review History: http://www.sciencedomain.org/review-history/2253
Cyclic voltammetric technique has been used for investigation of electrochemical parameters of antihypertensive drug, Losartan Potassium. This drug is usually used for the treatment of blood pressure, type II diabetic disease with proteinuria and stroke prevention. In this study Britton Robinson buffer was used as supporting electrolyte at room temperature30±1ºC and peak potential (Epc), Peak current(Ipc), transfer coefficient (α) and diffusion coefficient (D) were estimated at different scan rates, pH and concentration. The electrochemical process was found to be adsorption controlled and irreversible. Furthermore, Losartan Potassium represents transfer of two electrons during reduction reaction.
Cyclic voltammetry; Losartan Potassium; Electrochemical parameters; Gold electrode; Antihypertensive drug.
Full Article - PDF Page 128-136
DOI : 10.9734/IRJPAC/2014/5471Review History Comments