Quick Menu

Upcoming Journals

European Journal of Medicinal Plants

European Journal of Medicinal Plants, ISSN: 2231-0894,Vol.: 4, Issue.: 1 (January)


Screening for Antimicrobial Activity of Cissampelos pareira L. Methanol Root Extract


Njeru S. Ngoci1*, Musa Ramadhan2, Mwaniki S. Ngari3,5 and Oduor P. Leonard4

1Department of Medicine, Kisii University, Faculty of Health Sciences, PO Box 408, Kisii, Kenya.
2Department of Pathology, Rift Valley Provincial General Hospital, PO Box 71, Nakuru, Kenya.
3Department of Chemistry, Kisii University, Faculty of Science, PO Box 408, Kisii, Kenya.
4Department of Biological Sciences, Egerton University, PO Box 536, Egerton, Kenya.
5Department of Chemistry, Egerton University, PO Box 536, Egerton, Kenya.


Article Information


(1) Kaliyaperumal Karunamoorthi, Medical Entomologist College of Public Health & Medical Sciences, Jimma University, Ethiopia.

(2) T. A. tor-Anyiin, Natural Product Organic/Medicinal Chemistry, Department of Chemistry, Federal University of Agriculture, Makurdi, Nigeria.


(1) Anonymous.

(2) Anonymous.

(3) Anonymous.

Complete Peer review History: http://www.sciencedomain.org/review-history/2227




Aims: To screen for the antibacterial activity of Cissampelos pareira L. using six bacteria (Two Gram positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and four Gram negative bacteria (Escherichia coli, Pseudomonas aeroginosa, Klebsiella pneumoniae and Proteus vulgaris). The phytochemicals that are responsible for the bioactivity were also screened.
Study Design: An In vitro antibacterial assay was done using disc diffusion.
Place and Duration of Study: Samples were collected from Mbeere community, Embu county-Kenya. Authentication of botanical identity was done at the department of biological sciences while extraction and phytochemical analysis was undertaken in the department of Chemistry, Egerton University-Kenya. Antimicrobial bioassay was carried out at Department of Microbiology, Rift Valley Provincial General Hospital.
Methodology: Disc diffusion test was used to determine antimicrobial activity to plant extracts. Chemical tests were used to determine the group of phytochemicals present in the sample extract.
Results: Cissampelos pareira L. methanol root extract demonstrated antibacterial activity to four of the six tested bacteria. The highest inhibition was demonstrated toward S. aureus (20 mm), S. typhimurium (17 mm), K. pneumoniae (14 mm) and E. coli at (9 mm). P. vulgaris and S. pneumoniae were not sensitive to the extract at all. The phytochemical screening demonstrated the presence of all phytochemicals tested (alkaloids, flavonoids, tannins, terpenoids and steroids).
Conclusion: This study reveals that Cissampelos pareira L. has antibacterial activity to both Gram positive and Gram negative bacteria. This antibacterial activity is associated with the variety of phytochemicals found in this plant. Therefore, the plant has potential to be harnessed for further study in drug discovery.


Keywords :

Antibacterial activity; phytochemicals; root extracts; Cissampelos pareira L.; herb.


Full Article - PDF    Page 45-51    Article Metrics


DOI : 10.9734/EJMP/2014/5464

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.