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International Research Journal of Pure and Applied Chemistry

International Research Journal of Pure and Applied Chemistry, ISSN: 2231-3443,Vol.: 15, Issue.: 2


Synthesis and In vitro Antimicrobial Properties of Some New 4-(2-Benzoxy-3-ethoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol- 5-one Derivatives


Faruk Kardaş1, Özlem Gürsoy-Kol2*, Murat Beytur2, Muzaffer Alkan3 and Haydar Yüksek2

1Faculty of Education, Erzincan University, 24100 Erzincan, Turkey.

2Department of Chemistry, Kafkas University, 36100 Kars, Turkey.

3Faculty of Education, Kafkas University, 36100 Kars, Turkey.


Article Information


(1) Bengi Uslu, Department Analytical Chemistry, Ankara University, Ankara-Turkey.


(1) Ahmed Mohammed Abu-Dief Mohammed, Sohag University, Egypt.

(2) Claudia Araceli Contreras Celedon, Universidad Michoacana de San Nicolás de Hidalgo, México.

Complete Peer review History: http://www.sciencedomain.org/review-history/22162




Aims: The present study involved the synthesis of heterocycylic Schiff bases and their biological activity.

Study Design: Synthesizing some new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives and determining their chemical structure via IR and NMR spectroscopy. The synthesized compounds were analyzed for their in vitro potential antimicrobial and antioxidant activities.

Place and Duration of Study: Department of Chemistry, Kafkas University, Kars, Turkey. Between September 2010 to September 2012.

Methodology: Nine new 3-alkyl(aryl)-4-(2-benzoxy-3-ethoxy-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 2-benzoxy-3-ethoxy-benzaldehyde (2) which had also been synthesized by the reactions of 3-ethoxysalicylaldehyde with benzoyl chloride by using triethylamine.

Results: Schiff bases were synthesized and their structures were determined with spectral methods. Antimicrobial and antioxidant evaluation were carried out, presented and discussed.

Conclusion: Synthesis and structural determination of the new 3-alkyl(aryl)-4-(2-benzoxy-3-ethoxy-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) was successful. Considering both the antimicrobial and the antioxidant evaluation, compound 3c exhibited moderate effect.


Keywords :

1,2,4-Triazol-5-one; Schiff base; synthesis; antimicrobial activity; antioxidant activity.


Full Article - PDF    Page 1-9    Article Metrics


DOI : 10.9734/IRJPAC/2017/37845

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