Quick Menu

Upcoming Journals

Journal of Pharmaceutical Research International

Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 20, Issue.: 1


Antibacterial Activity of Ocimum gratissimum L. against Some Selected Human Bacterial Pathogens


Ajose Daniel Jesuwenu1* and Okozi Ogheneoremume Michael1

1Department of Biological Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria.


Article Information
(1) Othman Ghribi, Department of Pharmacology, Physiology & Therapeutics, University of North Dakota, USA.
(1) Ioana Stanciu, University of Bucharest, Romania.
(2) Aba-Toumnou Lucie, University of Bangui, Central African Republic.
Complete Peer review History: http://www.sciencedomain.org/review-history/22159




Aim: This study was designed to investigate the bioactive spice to determine its activity against some selected human bacterial pathogens. The spice studied was Ocimum gratissimum (clove basil).

Place and Duration of study: Microbiology laboratory of Bells University of Technology between October, 2016 to July, 2017.

Methodology: The plant extracts was tested for their activity against Staphylococcus species, Escherichia coli, Enterococcus faecalis, Proteus mirabilis and Klebsiella pneumoniae collected from microorganism bank of Bells University of Technology. Antibacterial activity was carried out using agar diffusion method while agar dilution method was employed for determining the minimum inhibitory concentration (MIC) on Mueller-Hinton agar.  

Results: The findings of this study showed that the spice contained phytochemicals which made it active against the tested microorganisms. Hot water extract was more active against all tested isolates with MIC of 5.0 mg/ml against Klebsiella pneumoniae to 10 mg/ml against Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Enterococcus faecalis. Zone of inhibition was between 18 mm for Staphylococcus aureus and Enterococcus faecalis and 31 mm for Proteus mirabilis.

Conclusion: Ocimum gratissimum has a broad spectrum antibacterial activity against all tested isolates and thus has a potential as a source of natural drugs. However, in vivo studies are recommended.


Keywords :

Spice; Ocimum gratissimum; human pathogen; agar diffusion.


Full Article - PDF    Page 1-8    Article Metrics


DOI : 10.9734/JPRI/2017/37897

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.