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Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 20, Issue.: 1

Original-research-article

Investigate the Effect of Fatty Acids on Rheological Properties and In vitro Permeability of Escitalopram Oxalate from Hydroxypropyl Cellulose Gel Formulations

 

Nisarg Modi1,2, Marina Borovinskaya2, Fotios Plakogiannis2 and Rutesh Dave1*

1Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY-11201, USA.

2Transdermal Research Pharm Laboratories, Pharmaceutical R&D Department, LLC, Long Island City, NY-11101, USA.

Article Information
Editor(s):
(1) Rafik Karaman, Professor, Bioorganic Chemistry, College of Pharmacy, Al-Quds University, USA.
Reviewers:
(1) Norma Aurea Rangel Vazquez, Mexico.
(2) Filip Nina, University of Medicine and Pharmacy Gr. T. Popa Iasi, Romania.
Complete Peer review History: http://www.sciencedomain.org/review-history/22137

Abstracts

The present studies evaluate rheological properties and in-vitro permeability properties of Escitalopram Oxalate (ECO) containing hydroxypropyl cellulose (Klucel HF, HPC) gels prepared with different carbon chain length containing fatty acids. The formulations were prepared by mixing solvent, escitalopram oxalate and kulcel HF (HPC) in homogenizer at 25000 RPM. A controlled stress rheometer was used to study the effect of different number of carbon chain fatty acids on the rheological properties and microstructure of HPC gels. The in-vitro permeability study was performed using human cadaver skin in order to evaluate the enhancing effect of fatty acids. The studies demonstrated that as the carbon chain length increased (C10-C18) the zero-shear viscosity, and yield stress value increased, which suggested that the stability of gel structure was increased with increase in carbon chain of fatty acids. Cohesive Energy was also depended on the carbon chain of fatty acids. There was decreased in cohesive energy as decrease in carbon chain of fatty acids. Temperature loop was created using heating and cooling temperature cycle. Oleic acid (C18) gave the best thermal stability with lowest temperature loop area. Increase in carbon chain length of fatty acids decreased the permeability enhancing effect of Escitalopram Oxalate through human cadaver skin during In-vitro permeability studies. The permeability of ECO through human cadaver skin was found to be in increasing order as capric acid> lauirc acid> Oleic acid> No-enhancer. Rheological studies could be useful to investigate the internal structure of HPC gels. Fatty acids alter the rheological properties of HPC gels such as zero shear viscosity, yield stress and cohesive energy. Moreover, In-vitro permeability results demonstrated that HPC gels containing fatty acids could be potential delivery system for transdermal delivery of ECO.

Keywords :

Polymer rheology; microstructure; fatty acids; diffusion; transdermal; escitalopram oxalate; viscosity; cohesive energy.

Full Article - PDF    Page 1-10 Article Metrics

DOI : 10.9734/JPRI/2017/37901

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