British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 1, Issue.: 4 (October-December)
Original Research Article
Didanosine Exposure and Noncirrhotic Portal Hypertension in a HIV Clinic in North America: a Follow-up Study
Edward R. Cachay1*, Michael R. Peterson2, Miguel Goicoechea1 and William C. Mathews1
1Department of Medicine, University of California at San Diego, San Diego, California, United States.
2Department of Pathology, University of California at San Diego, San Diego, California, United States.
Aims: To describe: 1) our cohort of patients diagnosed with NCPH in a HIV academic clinic in North America, and 2) longitudinal follow-up and outcomes of patients following NCPH diagnosis.
Study design: Retrospective case series
Place and Duration of Study: Owen clinic, University of California, San Diego, United States, between October 1990 and December 2010.
Methodology: We describe a cohort of patients diagnosed with NCPH in a HIV academic clinic with emphasis on their follow-up and outcomes after NCPH diagnosis.
Results: During the study period, eight HIV-infected men were diagnosed with NCPH. All patients were exposed to Didanosine (ddI) for a median of 37 months. One patient died soon after NCPH diagnosis due to a condition unrelated to NCPH. The other seven patients have received B-blocker therapy and annual esophago-gastro-duodenectomy screenings with banding of esophageal varices when indicated and remain still alive. Three patients were on ddI at the time of NCPH diagnosis. In one patient ddI was discontinued shortly after NCPH diagnosis. The other two patients continued to use ddI after NCPH diagnosis and developed recurrent upper gastrointestinal bleeding in the subsequent 2 years, requiring revascularization interventions. The four patients that were already off ddI at the time of NCPH diagnosis have been followed for a median of 6 years. These four patients remained minimally symptomatic for up to 16 years of follow-up from NCPH diagnosis.
Conclusion: When ddI was discontinued before portal hypertension was clinically apparent the progression of NCPH appeared to subside without major clinical complications.
Noncirrhotic portal hypertension; HIV; didanosine;
Full Article - PDF
DOI : 10.9734/BJMMR/2011/554