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International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 19, Issue.: 4

Original-research-article

Acute Phase Reactant Profile of Subjects with Prediabetes and Type 2 Diabetes Mellitus

 

 N. Chandrika1* and S. M. R. Usha2

1Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, India.

2Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, India.

Article Information
Editor(s):
(1) Mohamed Fawzy Ramadan Hassanien, Biochemistry Department, Faculty of Agriculture, Zagazig University, Egypt.
Reviewers:
(1) Yuji Aoki, Matsumoto Medical Center Matsumoto Hospital, Japan.
(2) Keagile Bati, University of Botswana, Botswana.
(3) Takashi Ikeno, National Center of Neurology and Psychiatry, Japan.
Complete Peer review History: http://www.sciencedomain.org/review-history/21727

Abstracts

Aim: The aim of the study is to examine the acute phase reactants in the backdrop of insulin resistance represented by prediabetic and overt diabetic states.

Study Design: Cross sectional study

Place and Duration of the Study: The study was undertaken at Rajarajeswari Medical college and Hospital, Bengaluru for around six months between July 2013 and December 2013.

Methodology: The study consists of three groups. We incorporated the World health organisation criteria for the diagnosis of prediabetes and type 2 diabetes mellitus.  Accordingly forty seven adults were included in the first prediabetic group, the second group comprised of thirty seven type 2 diabetes mellitus patients.  Thirty age and sex matched healthy volunteers constitued the third group. We intend to study High sensitive C reactive protein, serum albumin and serum uric acid levels, estimated by standard methods in the three groups.

Results: The Mean and standard deviation of HsCRP in prediabetic, T2DM and controls are 4.09±1.29, 3.38±1.41 and 1.68±0.51 mg//L respectively (p=0.030) in the present study. The serum albumin levels exhibit a statistically significant (p=0.001) downward trend from 4.67±0.49 g/dl in the  healthy controls to 4.01±0.44 g/ dl in prediabetics and 3.96±0.55 g/dl in diabetics. We have not noticed any statistically significant difference in the levels of uric acid among the three groups.

Conclusion: The acute phase reactant profile corresponds to the inflammatory environment and worsens as the disease progresses, in a metabolic disorder like T2DM, which is apparently evident in our study.

Keywords :

Acute phase reactants; prediabetes; type 2 diabetes mellitus; inflammation.

Full Article - PDF    Page 1-6

DOI : 10.9734/IJBCRR/2017/37785

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