International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 19, Issue.: 4
Acute Phase Reactant Profile of Subjects with Prediabetes and Type 2 Diabetes Mellitus
N. Chandrika1* and S. M. R. Usha2 1Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, India. 2Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, India.
N. Chandrika1* and S. M. R. Usha2
1Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, India.
2Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, India.
(1) Mohamed Fawzy Ramadan Hassanien, Biochemistry Department, Faculty of Agriculture, Zagazig University, Egypt.
(1) Yuji Aoki, Matsumoto Medical Center Matsumoto Hospital, Japan.
(2) Keagile Bati, University of Botswana, Botswana.
(3) Takashi Ikeno, National Center of Neurology and Psychiatry, Japan.
Complete Peer review History: http://www.sciencedomain.org/review-history/21727
Aim: The aim of the study is to examine the acute phase reactants in the backdrop of insulin resistance represented by prediabetic and overt diabetic states.
Study Design: Cross sectional study
Place and Duration of the Study: The study was undertaken at Rajarajeswari Medical college and Hospital, Bengaluru for around six months between July 2013 and December 2013.
Methodology: The study consists of three groups. We incorporated the World health organisation criteria for the diagnosis of prediabetes and type 2 diabetes mellitus. Accordingly forty seven adults were included in the first prediabetic group, the second group comprised of thirty seven type 2 diabetes mellitus patients. Thirty age and sex matched healthy volunteers constitued the third group. We intend to study High sensitive C reactive protein, serum albumin and serum uric acid levels, estimated by standard methods in the three groups.
Results: The Mean and standard deviation of HsCRP in prediabetic, T2DM and controls are 4.09±1.29, 3.38±1.41 and 1.68±0.51 mg//L respectively (p=0.030) in the present study. The serum albumin levels exhibit a statistically significant (p=0.001) downward trend from 4.67±0.49 g/dl in the healthy controls to 4.01±0.44 g/ dl in prediabetics and 3.96±0.55 g/dl in diabetics. We have not noticed any statistically significant difference in the levels of uric acid among the three groups.
Conclusion: The acute phase reactant profile corresponds to the inflammatory environment and worsens as the disease progresses, in a metabolic disorder like T2DM, which is apparently evident in our study.
Acute phase reactants; prediabetes; type 2 diabetes mellitus; inflammation.
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