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International Blood Research & Reviews, ISSN: 2321-7219,Vol.: 7, Issue.: 4


Assessment of CD4 Count and Some Haematological Parameters of HIV Positive Patients Co-infected with Hepatitis B Virus in Osun State, Nigeria


Digban Awharentomah Kester1, Osula Ivie1, Adesina Ebun Beatrice2, Aghatise Kevin1 and Enitan Seyi Samson3*

1Department of Medical Laboratory Science, Igbinedion University Okada, Edo State, Nigeria.

2Department of Medical Laboratory Services, State Specialist Hospital Osogbo, Osun State, Nigeria.

3Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria.

Article Information
(1) Dharmesh Chandra Sharma, Incharge Blood Component & Aphaeresis Unit, G. R. Medical College, Gwalior, India.
(1) D. Atere Adedeji, Achievers University, Nigeria.
(2) Lívia Garcia Bertolacci-Rocha, Universidade Federal de Goiás, Brasil.
Complete Peer review History: http://www.sciencedomain.org/review-history/21484


Background: Increased morbidity and mortality rates have been reported among patients co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV).

Aims: To determine the prevalence of HBV infection among HIV-infected anti-retroviral therapy (ART) naïve patients attending two Public Health Facilities in Osun State, Nigeria; as well as to determine the effect of HIV/HBV co-infections on CD4 count and some haematological parameters.

Study Design: This is a prospective, analytical and Institutional based study.

Place and Duration of Study: HIV Out-Patients Clinic, State Specialist Hospital Osogbo and State Hospital Iwo, Osun State, Nigeria, between February and August, 2015.

Methodology: A total of 321 blood samples were collected from 121 HIV HAART Naïve patients and 200 HIV negative patients, aged between 4 and 52 years. HIV antibodies were detected using 3 rapid diagnostic kits (Determine, Unigold and Stat Pak). Hepatitis B surface antigen (HbsAg) was detected using Clinotech Diagnostic test strips. CD4+ cells were counted using Partec® Cyflow Counter (Germany); while Platelet Count and Haemoglobin concentration were determined using Sysmex auto-analyzer (Japan).

Results: The prevalence of HBV infection was found to be significantly higher (P<0.05) among HIV positive patients (16.5%) than in HIV negative patients (3.5%). HIV status was identified as a risk factor for acquiring HBV infection. There were no significant differences between the CD4 Count, Platelet Count and Haemoglobin Concentration of HIV/HBV co-infected and mono-infected group on the basis of age, except for gender. The mean CD4 Count of HIV/HBV co-infected males (327±200.64 Cells/µL) was found to be significantly higher (P<0.05) than their mono-infected counterparts (274.5±81.33 Cells/µL), whereas, their Platelet Count and haemoglobin concentration did not differ significantly (P>0.05). Also, the mean CD4 cell count of co-infected females (408.4±331.28 Cell/µL) was significantly (P<0.05) higher than that of their male counterparts (327.6±81.33 Cell/µL). However, there were no significant differences in their mean platelet count and haemoglobin concentration.

Conclusion: HBV exist among HIV positive patients living in Osun State, Nigeria, with a prevalence rate of 16.5%. Although, no significant difference was observed in the Platelet count and Haemoglobin concentration of HIV/HBV co-infected when compared to those of HIV mono-infected patients, regular monitoring of their CD4 Count, Platelet Count and Haemoglobin Concentration is encouraged to prevent associated sequalea.

Keywords :

HIV/HBV co-infection; CD4 count; platelet count; haemoglobin concentration.

Full Article - PDF    Page 1-13

DOI : 10.9734/IBRR/2017/36160

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