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Biotechnology Journal International

Biotechnology Journal International, 2456-7051,Vol.: 19, Issue.: 4


Inhibitory Effects of 4T1 Breast Tumor Transplantation on Mouse Peripheral Blood Immune Cell Populations


Kexin Zheng1, Qilong Li2, Chenghao Fu2 and Shiliang Ma1,2*

1College of Food Science and Technology, Shenyang Agricultural University, 120 Dong-Ling Road, Shenhe District, Shenyang, Liaoning Province, 110866, P.R. China.

2College of Bioscience and Biotechnology, Shenyang Agricultural University, 120 Dong-Ling Road, Shenhe District, Shenyang, Liaoning Province, 110866, P.R. China.


Article Information
(1) Jianxiang (Jason) Chi, Head of Molecular Haematology Laboratory, Head of CytoGenomics Laboratory, The Center for the study of haematological malignancies (CSHM)/Karaiskakio Foundation, Nicosia, Cyprus.
(1) Asita Elengoe, Lincoln University College, Malaysia.
(2) Carla Maria Ferreira Guerreiro da Silva Mendes, Universidade Católica Portuguesa. Enfermeira Especialista em Saúde
Infantil e Pediatria no Centro de Saúde de São João. Docente na Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisboa, Portugal.
Complete Peer review History: http://www.sciencedomain.org/review-history/21290




Aims: One of serious threats to women's health is mammary cancer whose occurrence, development, and treatment are related to the body’s immunological circumstances. In addition, the cancer also imposes the some effects on the body’s immune system. However, the body’s response is very diverse because it varies from type to type of cancer. This paper reported that the effects of 4T1 cell transplantation on immune cells and spleen in mice.

Methods: Twenty female BALB/C mice were randomly divided into a control group and transplantation group. 4T1 cells were injected into the forth mammary fat pad to construct an animal model of breast cancer metastasis. The lymphocytes from mouse peripheral blood after transplantation and were analyzed by flow cytometry.

Results: The transplantation of 4T1 cells rapidly and continuously decreased the percentages of total T cells, total B cells, cytotoxic T cells and helper T cells in peripheral blood during experimental period (28 days). In addition, memory T cells in the transplantation group were increased at 28 days after transplantation. Only the natural killer (NK) cell percentage was significantly increased at 14 days after transplantation.

Conclusions: 4T1 cell transplantation exerted distinctive effects on the different types of immune cells in mouse peripheral blood: the transplantation of 4T1 cells decreased the levels of total T cells, total B cells, cytotoxic T cells, helper T cells and memory T cells, and the natural killer (NK) cell was increased transiently than in control group.


Keywords :

T cell; B cell; NK cell; breast cancer; BALB/C mice.


Full Article - PDF    Page 1-12    Article Metrics


DOI : 10.9734/BJI/2017/36382

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