Quick Menu

Upcoming Journals

Journal of Advances in Medicine and Medical Research

Journal of Advances in Medicine and Medical Research, ISSN: 2456-8899, ISSN: 2231-0614 (Past),Vol.: 24, Issue.: 1


Paraoxonase Arylestarase and Oxıdatıve Stress in Coronary Artery Surgery Technıques with Desflurane Anesthesıa


Arslan Onuk Asuman1*, Yegin Ayşenur2, Ellidağ Hamit Yaşar2, Arslan Barış1, Emmiler Mustafa3, Karslı Bilge1 and Yılmaz Necat2

1Department of Anesthesiology, Antalya Education and Research Hospital, Antalya, Turkey.

2Department of Clinic Biochemistry, Antalya Education and Research Hospital, Antalya, Turkey.

3Deparment of Cardiovascular Surgery, Antalya Education and Research Hospital, Antalya, Turkey.


Article Information


(1) Murali P. Vettath, Department of Cardiovascular-Thoracic & HeartTransplantation, Director-International Center of Excellence in OPCAB surgery, Malabar Institute of Medical sciences, Govindapuram, Kozhikode, Kerala, India.


(1) Hani Mufti, Royal Children’s Hospital Melbourne, Australia.

(2) Maddury Jyotsna, Deemed University, India.

(3) Takeshi Shirayama, Kyoto Prefectural University of Medicine, Japan.

(4) Gerez Fernandes Martins, State Institute of Cardiology, Brazil.

Complete Peer review History:




Background: Cardiovascular disease is the leading cause of morbidity in older people. Coronary artery bypass graft surgery is the most common type of operation performed in the world. Oxidative stress occurs in patients undergoing coronary artery bypass operation. The aim of this study was to investigate the difference in oxidative stress in off-pump versus on-pump coronary artery bypass surgery. We investigated patients undergoing traditional (on-pump) bypass surgery and bypass surgery performed on a beating heart (off-pump) who had been given antioxidant enzymes for high-density lipoprotein, as well as measured the levels of paraoxonase-1 (PON1), arylestarase (ARE), total antioxidant capacity (TAS), total oxidative stress (TOS), and oxidative stress index (OSI).

Methods: A total of 40 patients (29 males, 11 females) underwent traditional on-pump bypass, and 30 (24 males, 6 females) underwent off-pump bypass. PON1, ARE, TAS, and TOS levels were measured, and OSI was calculated.

Results: Preoperative and postoperative parameters were compared in the on-pump group, and only high OSI levels (P = .02) were found. No significant difference in operative parameters was found in the off-pump group. The serum values of OSI and TOS, were significantly greater in the on-pump group (P = .007, P = .008). Serum total cholesterol, HDL, low-density lipoprotein (LDL), triglyceride, and OSI levels were significantly higher preoperatively (after anesthesia induction) compared with the levels postoperatively (P < .001, P = .04, P = .007, P < .001, and P = .02, respectively) in the on-pump group, whereas the difference in the PON1, ARE, TAS, and TOS levels were not statistically significant.  No significant difference was found in the other parameters.

Conclusions: On-pump bypass has long been considered the “gold standard” of treatment. However, our study has revealed that the newly developed beating heart off-pump bypass method results in less exposure of the patient to circulatory oxidative stress. Further studies are needed in order to confirm this hypothesis.


Keywords :

Paraoxonase; arylesterase; total antioxidant capacity; total oxidant stress; cardiac bypass.


Full Article - PDF    Page 1-8    Article Metrics


DOI : 10.9734/JAMMR/2017/34684

Review History    Comments

Search this site

Advanced Search

Announcement & News

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.