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Annual Research & Review in Biology

Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 17, Issue.: 3

Original-research-article

Assessment of Serum Lipid Profile in HIV-AIDS Patients Attending Sir Yahaya Memorial Hospital Birnin-Kebbi, Nigeria

 

F. U. Bunza1* and I. Z. Wasagu1

1Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.

 

Article Information
Editor(s):
(1) George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.
Reviewers:
(1) Lívia Garcia Bertolacci-Rocha, Universidade Federal de Goiás, Brasil.
(2) Kamgain Mawabo Lugarde, District Hospital of Deido, Cameroon.
(3) Gloria Maria Molina-Salinas, Instituto Mexicano del Seguro Social, Mexico.
Complete Peer review History: http://www.sciencedomain.org/review-history/21017

 

Abstracts

 

Aims: To assess lipid profile among HIV patients on ART, ART-naïve patients and controls in our environment.

Study Design: This is a cross-sectional study of 120 participants consisting of 40 HIV patients on ART, 40 ART-naïve patients and 40 negative controls.

Place and Duration of Study: Antiretroviral Clinic, Sir Yahayya Memorial Hospital, Birnin-Kebbi and Chemical Pathology Department, Usmanu Danfodiyo University, Sokoto, between March, 2016 and June, 2016.

Methodology: Serum total cholesterol, triglyceride and high-density lipoprotein-cholesterol (HDL-c) were assayed based on enzymatic methods using SELECTRA XL automated chemistry analyzer with analysis in batches. LDL-c and atherogenic index (AI) was calculated using Friedwald’s formula (LDL-c = TC-(TG/2.2)-HDL-c mmol/L) (Satya, 2011) and TC/HDL-c respectively.

Results: Our result showed that the mean values of TC and HDLc was significantly higher (p<0.01) in HIV patients on ART compared to controls. The serum LDL-c was significantly lower (p<0.05) between patients on ART and controls. AI was significantly lower (p<0.01) in HIV patients on ART compared to controls. There was no statistically significant difference in TC and AI (P>0.05) between ART-naïve HIV-patients and controls. However, statistically significant difference was observed in BMl and LDL-c (P<0.05) in ART-naïve HIV-patients and controls. No statistically significant difference observed in the mean age, TG and LDL-c (P>0.05) between the patients on ART and ART-naïve patients. There was significant increase (P<0.05) in TC, HDL-c, AI and BMl in patients on ART compared to ART-naïve patients.

Conclusions: Our findings indicated that HIV infected patients have a host of variations in their lipid profile compared to HIV negative controls in our environment. The dyslipidemia levels, high LDL-c and TG were found in patients compared to control. ART could have additional advantage of enhancing HDL-c and may be associated with reduced risk for cardiovascular events.

 

Keywords :

HIV-AIDS patients; lipid profile; antiretroviral therapy; Birnin-Kebbi; Nigeria.

 

Full Article - PDF    Page 1-7    Article Metrics

 

DOI : 10.9734/ARRB/2017/35688

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