Quick Menu

Upcoming Journals

Journal of Pharmaceutical Research International

Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 18, Issue.: 4


Pharmacological Activities of Epithio Steroids


Valery M. Dembitsky1*, Tatyana A. Gloriozova2 and Vladimir V. Poroikov2

1Biochemistry Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, 690041, Russia.

2Institute of Biomedical Chemistry, Moscow, 119121, Russia.


Article Information
(1) Sanjay Nilapwar, Institute of Structural and Molecular Biology, University College London, London, UK.
(1) Mohini Chetan Kuchekar, Pune University, India.
(2) B. Vasudha, Jawaharlal Nehru Technological University, Telangana, India.
Complete Peer review History: http://www.sciencedomain.org/review-history/20901




The present review describes biological activities of semi- and synthetic epithio steroids. About fifty biologically active compounds have shown confirmed antitumor, immunosuppressant, or aromatase inhibition and other activities. More than a quarter of all studied steroids belong to the group of anabolic steroids, and they showed many new and additional activities. Epithio steroids possess mainly cytotoxic activities, although the predicted biological activity showed a broad spectrum of activities. As we found, the position of the epithio group in the core of steroids can significantly change the activity of steroids. The structures, as well as reported and predicted activities of a selection of epithio steroids, are reported. With the computer program PASS based on structure–activity relationships (SAR), some additional activities are also predicted, which point toward new possible applications of these lipids. This review emphasizes the role of epithio steroids as an important source of leads for drug discovery, and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.


Keywords :

Anabolic; steroids; ethylene sulphides; thiirane; epithio; lipidomics; activities.


Full Article - PDF    Page 1-19    Article Metrics


DOI : 10.9734/JPRI/2017/36199

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.