Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 18, Issue.: 2
Anti-inflammatory Activity and In silico Approaches on Root Extract of Decalepis hamiltonii Wight & Arn
Palanisamy Prakash1 and Rengarajan Manivasagaperumal1* 1Department Botany, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.
Palanisamy Prakash1 and Rengarajan Manivasagaperumal1*
1Department Botany, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.
(1) Rafik Karaman, Bioorganic Chemistry, College of Pharmacy, Al-Quds University, USA.
(1) Khadiga Ahmed Ismail, Ain Shams University, Egypt.
(2) Fidelis E. Olumese, University of Benin, Benin City, Nigeria.
(3) Dinithi Peiris, University of Sri Jayewardenepura, Sri Lanka.
(4) Ren-You Gan, The University of Hong Kong, Hong Kong.
Complete Peer review History: http://www.sciencedomain.org/review-history/20518
Aims: The present study was aimed to evaluate anti-inflammatory and antioxidant potential of methanol root extract of Decalepis hamiltonii.
Results: The methanolic extract showed in vitro anti-inflammatory activity inhibition cells 96.1%µg/ml. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was significant inhibited by the methanol (96.2) and inhibition addition the Nitric oxide production 25 µg/ml 95% inhibition. The methanol extract of Decalepis hamiltonii shows a Thus, a very strong approach to In-silico docking and in vitro anti-inflammatory study for whole with these compounds/extract.
Conclusion: From the study it is concluded that the root extract of Decalepis hamiltonii showing a strong approach to In-silico docking and anti inflammatory activity.
Decalepis hamiltonii; MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); nitric oxide; ferric reducing antioxidant power.
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DOI : 10.9734/JPRI/2017/32070Review History Comments