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Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 18, Issue.: 2

Original-research-article

Anti-inflammatory Activity and In silico Approaches on Root Extract of Decalepis hamiltonii Wight & Arn

 

Palanisamy Prakash1 and Rengarajan Manivasagaperumal1*

1Department Botany, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.

Article Information
Editor(s):
(1) Rafik Karaman, Bioorganic Chemistry, College of Pharmacy, Al-Quds University, USA.
Reviewers:
(1) Khadiga Ahmed Ismail, Ain Shams University, Egypt.
(2) Fidelis E. Olumese, University of Benin, Benin City, Nigeria.
(3) Dinithi Peiris, University of Sri Jayewardenepura, Sri Lanka.
(4) Ren-You Gan, The University of Hong Kong, Hong Kong.
Complete Peer review History: http://www.sciencedomain.org/review-history/20518

Abstracts

Aims: The present study was aimed to evaluate anti-inflammatory and antioxidant potential of methanol root extract of Decalepis hamiltonii.

Results: The methanolic extract showed in vitro anti-inflammatory activity inhibition cells 96.1%µg/ml. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was significant inhibited by the methanol (96.2) and inhibition addition the Nitric oxide production 25 µg/ml 95% inhibition. The methanol extract of Decalepis hamiltonii shows a Thus, a very strong approach to In-silico docking and in vitro anti-inflammatory study for whole with these compounds/extract. 

Conclusion: From the study it is concluded that the root extract of Decalepis hamiltonii showing a strong approach to In-silico docking and anti inflammatory activity.

Keywords :

Decalepis hamiltonii; MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); nitric oxide; ferric reducing antioxidant power.

Full Article - PDF    Page 1-8

DOI : 10.9734/JPRI/2017/32070

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