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International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 18, Issue.: 3

Original-research-article

Ameliorative Potentials of Egg Plant (Solanum melongena Linn) Fruit Ethanolic Extract on Monosodium Glutamate- Intoxicated Rats' Lipid Profile, Haematology and Heart Histology

 

Uchendu O. Mbah1* and Anthony Cemaluk C. Egbuonu1

1Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

Article Information
Editor(s):
(1) Richard A. Manderville, Departments of Chemistry and Toxicology University of Guelph, Canada.
Reviewers:
(1) Dharma Lindarto, Metabolic Division of H Adam Malik Hospital Medan, Indonesia.
(2) Anindita Banerjee, ICARE Institute of Medical Sciences & Research, India.
(3) Huei-Jane Lee, Chung Shan Medical University, Taiwan.
(4) Bhaskar Sharma, Suresh Gyan Vihar University, India.
Complete Peer review History: http://www.sciencedomain.org/review-history/20431

Abstracts

Aim: This study evaluated the ameliorative potentials of ethanolic extract of Solanum melongena Linn fruit on monosodium glutamate (MSG)-intoxicated rats' lipid profile, haematological parameters and heart histology using standard protocols.

Methodology: Twenty four Wistar rats that weighed 105.00 ± 7.00 g. The rats were assigned into six groups and fed thus: Group 1 (control, feed and 1 ml/kg body weight (bw) distilled water only), Group 2 (8000­ mg/kg bw MSG), Group 3 (300 mg/kg bw sample extract), Group 4 (8000 mg/kg bw MSG +100 mg/kg bw sample extract ), Group 5 (8000 mg/kg bw MSG+ 300 mg/kg bw sample extract) and Group 6 (8000 mg/kg bw MSG+ 500 mg/kg bw sample extract) daily for 14 days.

Results: There were significant (P =.05) increase in total cholesterol, triacylglyceride (TAG), very low density lipoprotein (VLDL) and low density lipoprotein cholesterol (LDL-c) and significantly (P =.05) decrease in high density lipoprotein cholesterol (HDL-c) in only MSG fed group compared to the control group. Interestingly, MSG co-administration with ethanolic extract of Solanum melongena Linn fruit for group 4, 5 and 6 showed significant (P=.05) reduction in serum total cholesterol, TAG, VLDL and LDL-c and increased HDL-c. There was no significant (P =.05) difference in the haematological parameters (Red blood cell, hemoglobin and hemacrit) except for white blood cell count which was significantly (P =.05) reduced in the MSG fed group. The histological results revealed that MSG ingestion in rats induced toxic injuries in their hearts at 8000 mg/kg body weight and effects were slowly being ameliorated as the concentration of the ethanolic extract of Solanum melongena Linn fruit increased.

Conclusion: This study confirmed general adverse influence of MSG at a high concentration (8000 mg/kg body weight) and demonstrated the ameliorative role of ethanolic extract of Solanum melongena Linn fruit, notably at 300 mg/kg of body weight, on the studied monosodium glutamate-intoxicated bio-functions in rats.

Keywords :

Solanum melongena Linn fruit; MSG–intoxication; lipid profile; haematology and heart histology.

Full Article - PDF    Page 1-10

DOI : 10.9734/IJBCRR/2017/35057

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