Quick Menu

Upcoming Journals
  • No Upcoming Journals

Journal of Pharmaceutical Research International

Journal of Pharmaceutical Research International, XXXX,Vol.: 17, Issue.: 3

 

Original-research-article

 

Assessment of Antiglycation Effects of Some Plants Used in Hypolipidaemic Formulations or as Spices

 

 

H. K. I. Perera1,2*, W. K. V. K. Premadasa2, W. I. T. Fernando1 and J. A. V. P. Jayasinghe3

1Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka.

2Postgraduate Institute of Science, University of Peradeniya, Sri Lanka.

3Department of Prosthetic Dentistry, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

 

Abstracts

 

Aims: Diabetes mellitus is characterized by hyperglycemia, which leads to acceleration of protein glycation. Some glycation products form inter molecular cross-links, contributing to chronic diabetic complications. Determination of protein glycation inhibitory potential of medicinal plants may offer safe therapeutic avenues in preventing diabetic complications. The aim of this study was to analyze the antiglycation effects of nine plants which included spices and some medicinal plants used in hypolipidaemic formulations.

Study Design: Experimental.

Place and Duration of Study: Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka between March 2014 and March 2015.

Methodology: Crude methanol extracts of nine, dried plant parts namely, Brassica juncea (BJ) seed, Coscinium fenestratum (CF) root, Cuminum cyminum  (CC) seed, Cyperus rotundus (CR) root, Foeniculum vulgare (FV) seed, Picrorhiza kurroa (PK) root, Acorus calamus (AC) rhizome, Trachyspermum roxburghianum (TR) leaf and Trigonella foenum-graecum (TF) seed and standard inhibitor aminoguanidine (AG) (1 mg/mL) were used. Inhibitory effects of plant extracts (0.5/ 2/ 5 mg/mL) on fructosamine formation, glycation and glycation induced cross-linking were assessed.

Results: Fructosamine formation was significantly inhibited (p<0.001) in the presence of CF, CR, PK and AC (2 mg/ ml). Antiglycation effects of these four plants were demonstrated when the extent of glycation was assessed using polyacrylamide gel electrophoresis. Protein cross-linking inhibitory effects of AC, CF, CR and PK extracts (2 mg/ ml) were revealed using sodium dodecyl polyacrylamide gel electrophoresis. At 0.5 mg/ ml, this inhibitory effect remained only in CR and PK. When 5 mg/ ml was used, BJ showed inhibitory effects while CC, TR and TF without an effect. Accordingly, the highest inhibitory effects were seen in CR and PK.

Conclusion: Antiglycation effects of root extracts of AC, CF, CR and PK were demonstrated with better effects in CR and PK.

 

Keywords :

Antiglycation; cross-linking; Cyperus rotundus; Picrorhiza kurroa.

 

Full Article - PDF    Page 1-8    Article Metrics

Review History    Comments

Search this site

Advanced Search

Announcement & News

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

Index Copernicus Value of British Journal of Medicine and Medical Research

  We are delighted to inform that Index Copernicus (a leading indexing organization ...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Publication and site statistics (up to Sept, 2015)

  Number of submission: 22181 (Total up to Sept, 2015) Number of published paper: 10949&n...

Index Medicus selected 15 SDI journals

We are delighted to inform that Index Medicus (IMSEAR) has selected following 15 SDI journals for in...

SCIENCEDOMAIN international received 5844 submissions in 2013

SCIENCEDOMAIN international is pleased to announce that it has received 5844 submissions in 2013, ac...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...



SCIENCEDOMAIN Awards

  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2017, SCIENCEDOMAIN international. All rights reserved.