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British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 16, Issue.: 6

Original-research-article

Anti-inflammatory and Hepatoprotective Potentials of Methanol Leaf Extract of Arachis hypogea

 

R. C. Ibeh1,2*, G. S. Aloh2, G. C Ikechukwu2, S. O. Ebhohon2, U. I. Edward2, C. J. Njoku2, F. O. Azubike-Izah2, E. U. Ejiofor2, C. I. Nwankwo2 and C. E. Oriaku2

1Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria.

2Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Nigeria.

Article Information
Editor(s):
(1) Salvatore Chirumbolo, Clinical Biochemist, Department of Medicine, University of Verona, Italy.
(2) Nawal Kishore Dubey, Centre for advanced studies in Botany, Banaras Hindu University, India.
(3) Ali Nokhodchi, Professor of Pharmaceutics and Drug Delivery, School of Life Sciences, University of Sussex, UK.
Reviewers:
(1) Fareeha Anwar, Riphah international University, Lahore, Pakistan.
(2) G. S. Casimiro, State University of Rio de Janeiro,Rio de Janeiro, Brazil.
(3) Abayomi Mayowa Ajayi, University of Ibadan, Oyo State, Nigeria.
Complete Peer review History: http://www.sciencedomain.org/review-history/19288

Abstracts

The anti-inflammatory and hepatoprotective properties of methanol extract of Arachis hypogea leaves were studied. At 400 mg/kg, the extract significantly suppressed the development of hind paw oedema induced by egg albumin, which compares favorably with a standard anti–inflammatory drug aspirin (acetylsalicylate) which at 100 mg/kg inhibits egg-albumin induced rat paw oedema. It was observed that the extract significantly inhibited platelet aggregation in a dose dependent fashion. At 0.6 and 0.7 mg/ml the percentage inhibition of platelet aggregation was observed to be 53.13 and 68.75% which compare closely to the standard drug indomethacin at 0.2 and 0.4 mg/ml which was found to be 53.13 and 65.63% respectively. Similarly, there was also an observable decrease in the activity of prostaglandin synthase which was dosage dependent at 0.1, 0.5 and 1 mg/ml, the percentage enzyme activity was 65, 70 and 95% respectively. Also, at 1 and 4 mg/ml of indomethacin, the percentage enzyme activity was 94.75 and 99.25% respectively. There was non-significant difference (P<0.05) in the selected liver function parameters assayed in all the groups after 21 days of administration. The study shows that the extract may contain anti-inflammatory agents with hepatoprotective properties and may yet serve as template for the development of more synthetic anti-inflammatory agents of clinical significance.

Keywords :

Anti-inflammation; Arachis hypogea; hepatoprotective; egg-albumin; aspirin and platelet.

Full Article - PDF    Page 1-12

DOI : 10.9734/BJPR/2017/33210

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