British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 21, Issue.: 6
Neuroprotective Role of Green Tea Polyphenols on the Superior Colliculus in MPTP Mice Model of Parkinson’s Disease
Philemon Dauda Shallie1*, Kanyinsola A. Koya2, Oluwadamilola Faith Shallie1 and Adedayo D. Adekomi3 1Department of Anatomy, Olabisi Onabanjo University, Nigeria. 2Department of Anatomy, Babcock University, Nigeria. 3Department of Anatomy, Osun State University, Nigeria.
Philemon Dauda Shallie1*, Kanyinsola A. Koya2, Oluwadamilola Faith Shallie1 and Adedayo D. Adekomi3
1Department of Anatomy, Olabisi Onabanjo University, Nigeria.
2Department of Anatomy, Babcock University, Nigeria.
3Department of Anatomy, Osun State University, Nigeria.
(1) Sarah Ralte, Department of Anatomy, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, India.
(1) Mario F. Guerrero, School of Sciences Universidad Nacional de Colombia, Colombia.
(2) Gonzalo Emiliano Aranda Abreu, Centro de Investigaciones Cerebrales, Universidad Veracruzana, Mexico.
(3) Pavol Svorc, Safarik’s University, Slovak Republic.
Complete Peer review History: http://www.sciencedomain.org/review-history/19035
Aim: This study investigated the neuroprotective role of green tea polyphenols on the superior colliculus of MPTP mice model of Parkinson’s disease.
Study Design: Twenty-five adult male mice (Mus musculus) weighing between 20-30 grams were used for this study. The mice were randomly placed into five groups of five mice each: A (Control; mice pellets), B (MPTP 10mg/kg, IP), C (MPTP + GT; 300 mg/kg GT orally), D (GT + MPTP), E (GT; 300 mg/kg).
Place and Duration of the Study: Department of Anatomy, Babcock University. Between February and May 2016.
Methodology: The brains were removed weighed and the midbrain excised processed histology and stained routinely with H&E and silver stains.
Results: The results showed significant (P<0.005) reduction in the relative brain to body weight and neuronal density in the superior colliculus; characterized by neuronal atrophy as signaled by vacuolations and pyknosis in the MPTP and green tea only groups. Whereas pre-treatment with green tea polyphenol resulted in significant (P<0.005) increase in the relative brain to body weight and increase in the superior colliculus neuronal density when compared with the MPTP and green tea only groups.
Conclusion: From our results we can conclude that pre-treatment with green tea polyphenols confers greater protection on the superior colliculus in MPTP mice model of Parkinson’s disease.
Parkinson’s disease; superior colliculus; MPTP; green tea polyphenol.
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DOI : 10.9734/BJMMR/2017/33329Review History Comments