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Journal of Advances in Medical and Pharmaceutical Sciences, 2394-1111,Vol.: 12, Issue.: 4

Original-research-article

Potential 5-Fluorouracil Encapsulated mPEG-Chitosan Nanogels for Controlling Drug Release

 

Dai Hai Nguyen1,2*

1Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam.

2Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

Article Information

Editor(s):

(1) Xiao-Xin Yan, Department of Anatomy & Neurobiology, Central South University Xiangya School of Medicine (CSU-XYSM), Changsha, Hunan 410013, China.

Reviewers:

(1) Syed Umer Jan, University of Balochistan, Pakistan.

(2) S. V. Patil, Ashokrao Mane College of Pharmacy, India.

(3) Mohd Abdul Hadi, Bhaskar Pharmacy College, Jntuh University, Hyderabad, India.

(4) Janaina Aline Galvão Barros, University of São Paulo, São Paulo, Brazil.

Complete Peer review History: http://www.sciencedomain.org/review-history/18587

Abstracts

Aims: The objective of this study was to prepare and characterize poly (ethylene glycol) methyl ether (mPEG)-conjugated chitosan (CS) nanogels, mPEG-CS, at different molar ratios for 5-Fluorouracil (5-FU) delivery (5-FU-loaded mPEG-CS nanogels).

Study Design: The chemical cross-linking of those polymers were synthesized by using 4-Nitrophenyl chloroformate as coupling reagent.

Place and Duration of Study: Department of Biomaterials & Bioengineering, Institute of Applied Materials Science, Vietnam Academy of Science and Technology, between February and June 2015.

Methodology: The chemical structure of mPEG-CS was characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR).

Results: The particle sizes of 5-FU-loaded nanogels were nearly spherical in shape with diameter range of 20-50 nm, determined by transmission electron microscopy (TEM). Especially, whereas the encapsulation efficiency and loading capacity of mPEG-CS nanogels were independent of the molar ratio of mPEG, there was one factor that particularly stand out, 5-FU release behavior.

Conclusion: These results demonstrated that mPEG-CS nanogels present potential for controlled release of 5-FU working as a delivery system in cancer therapy.

Keywords :

Poly (ethylene glycol) methyl ether; chitosan; 5-fluorouracil; nanogels; drug delivery system.

Full Article - PDF    Page 1-7 Article Metrics

DOI : 10.9734/JAMPS/2017/32493

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