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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 20, Issue.: 2

Original-research-article

Family Risk of Metabolic Disorder; A Parameter for Timely Screening of Vascular Endothelial Health

 

Preeti Kanawjia1*, Sunita Tiwari2 and Manish Bajpai2

1Department of Physiology, GSVM Medical College, Kanpur, India.

2Department of Physiology, King George's Medical University (KGMU), Lucknow, India.

Article Information

Editor(s):

(1) Vijayalakshmi I. Balekundri, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India.

(2) Syed Faisal Zaidi, Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University-HS, National Guard Health Affairs, King Abdulaziz Medical City, Kingdom of Saudi Arabia.

(3) Chan Shen, Department of Biostatistics, MD Anderson Cancer Center, University of Texas, USA.

Reviewers:

(1) Alessio D’Alessio, Catholic University of the Sacred Heart, Rome, Italy.

(2) Aline Cristina Tavares, Rehabilitation, Instituto do Câncer do Estado de São Paulo, Brazil and Rehabilitation, Hospital Sírio Libanês, Brazil and Rehabilitation, Instituto do Coração, Brazil.

(3) Moacir Marocolo Júnior, Federal University of Juiz de Fora, Brazil.

(4) Pietro Scicchitano, Hospital of Ostuni, Ostuni (Brindisi), Italy.

(5) Soumya Mishra, JIPMER, India.

Complete Peer review History: http://www.sciencedomain.org/review-history/18105

Abstracts

Aim: To study the correlation of vascular endothelial health with family risk of metabolic disorders, in healthy overweight, obese and non obese subjects.

Study Design: A case-control (pilot) study.

Place and Duration of Study: The study was conducted in Cardiovascular Physiology lab, Department of Physiology, K.G.M.U from January 2009 to February 2010.

Methods: Cases and controls comprised of 30 overweight/obese healthy subjects (BMI >= 25 kg/m2 and/or WHR (female>0.85; male>1) and 30 non-obese healthy subjects respectively (BMI< 25 kg/m2 and/or WHR (female<0.85; male<1) excluding subjects with secondary cause of abnormal blood flow. Vascular endothelial health was assessed via reactive hyperemic response measured via impedance plethysmography in the subject’s forearm. Fasting plasma glucose and serum lipid profile was also done.

Results: On comparison of biochemical variables, lipid derangement was recorded in both the groups.  Significant difference in VLDL (control 21.84±9.68, case 29.01±16.83) (p=0.048) and TG (control 101.22±-43.33; case145.21±84.02) (p=0.013), could be seen. VLDL & TG was deranged in 15 (6 cases + 9 controls) (P=0.371) and 14 (5 cases + 9 controls) (P=0.222) subjects respectively with no inter-group significant statistical difference. Inter-group reactive hyperemia at 1, 2, 3, 5, 7, 9 min post occlusion time showed no significant difference. Peak hyperemic response was seen at 2 minutes in both the groups. Though independent family history in first degree relatives of diabetes, coronary artery disease and/or hypertension showed a significant association with % RH at 2 min. (P=0.049), yet in group wise exploration, no significant association was seen.

Conclusion: Adverse anthropometry is universally not associated with deranged lipid profile and vice versa. Raised RH response associated with positive family risk could be either due to hyperinsulinemia and/or some yet undeciphered cause but not solely as add-on sequelae of deranged anthropometry (BMI & WHR).

Keywords :

Reactive hyperemia; impedance plethysmography; vascular endothelial health.

Full Article - PDF    Page 1-10

DOI : 10.9734/BJMMR/2017/31004

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