Quick Menu

Upcoming Journals

Journal of Advances in Medical and Pharmaceutical Sciences

Journal of Advances in Medical and Pharmaceutical Sciences, 2394-1111,Vol.: 12, Issue.: 1

Original-research-article

Effects of Aqueous Leaf Extract of Annona muricata on Pregnancy and Pregnancy Outcome

 

Enyi Obianuju1, Okorie Pamela1, Iyare Eghosa1, Ugwu Princewill1 and Anyaehie Ugochukwu Bond1*

1Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.

 

Article Information

Editor(s):

(1) Erich Cosmi, Department of Woman and Child Heath, University of Padua, Italy.

(2) Hamdy A. Sliem, Internal Medicine, Suez Canal University, Egypt And College of Dentistry, Qassim University and EL-Jouf University, Saudi Arabia.

Reviewers:

(1) O. Imoru Joshua, Obafemi Awolowo University, Ile-Ife, Nigeria.

(2) Noha S. Khalifa, Ain Shams University, Cairo, Egypt.

(3) Samsudeen Gbenga Ojuolape, Abubakar Tafawa Balewa University, Bauchi, Nigeria.

Complete Peer review History: http://www.sciencedomain.org/review-history/18005

 

Abstracts

 

Background: Indiscriminate and increasing consumption of herbal medicinal products by pregnant women presents major concern due to paucity information on safety. Annona muricata also known as soursop is commonly consumed in Nigeria including by pregnant women, but information remains poor on effects on pregnancy outcomes.

Aims and Objectives: This study was carried out to determine the effect of the aqueous extract of Annona muricata leaves on maternal weight gain during pregnancy, placental weight, litter size, body weight at birth and placental/body weight ratio in female Wistar rats.

Materials and Methods: Twenty-four (24) female Wistar rats were used for this study. On confirmation of pregnancy by presence of spermatozoa in vaginal smears and  vaginal plugs in cages, the rats were then divided into four groups of six rats each receiving different concentration of the extract as follows; 15 mg, 30 mg, and 45 mg/kg of body weight. The extract was administered orally and daily throughout the gestational period of the Wistar rats. The maternal body weights were measured daily; before extract administration, during extract administration and prior to sacrifice.  On day 18 of pregnancy, 4 rats from each group were sacrificed; placentae harvested and weighed using analytical weighing balance. The foetal number in utero were also determined and recorded. On the day of delivery for the remaining 2 rats, the gestational length, litter size and birth weight were recorded and litter length measured to the nearest (cm) using a measuring tape. Morphological appearance of the offspring was also assessed.

Statistics: Data obtained as mean ± standard deviation were analysed using one way analysis of variance (ANOVA) followed by a post hoc student’s Neuman-Keul’s test. Level of significance between groups was taken as p<0.05.

Results:  There was a significant reduction in maternal weight during pregnancy, litter birth weight, litter length, placental weight and placental/birth weight ratio of the extract-treated pregnant group (p<0.05) compared to control group.

Conclusion: Consumption of Annona muricata by pregnant women can significantly reduce the utero-placental transfer of nutrients and as a consequence impair fetal growth.

 

Keywords :

Pregnancy; herbal; Annona muricata; Nigeria.

 

Full Article - PDF    Page 1-6    Article Metrics

 

DOI : 10.9734/JAMPS/2017/31444

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...



SCIENCEDOMAIN Awards

  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.