British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 14, Issue.: 5
Original Research Article
Evaluation of Hypolipidemic Activity of Allium schoenoprasum in Albino Rats
Aamir Mushtaq1*, Shazma Farhat Naqvi2, Rukhsana Anwar3, Mehwish Jamil2, Habib Anwar2, Asifa Bashir2, Qurat-ul-Ain2 and Baderqa tul Ayesha2
1Gulab Devi Institute of Pharmacy, Gulab Devi Educational Complex, Lahore, Pakistan.
2Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan.
3University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
Aim of Study: This study was designed to evaluate the hypolipidemic action of aqueous and ethanolic extracts of leaves of Allium schoenoprasum in albino rats.
Methodology: 500 g of dried leaves powder was initially soaked in 3 L of 99.9% ethanol for three days and after filtration residues was soaked in 2 L distilled water for further three days. Both filtrates were subjected to rotary evaporator to get semi solid pastes. Rats were divided in five groups with six animals in each group. Hyperlipidemia was induced in rats by intraperitoneal administration of Triton X-100 (100 mg/kg/ip). After 72 hours, normal group was given normal saline while hyperlipidemic protocols were given to other groups. 200 mg/kg/p.o dose of ethanolic and aqueous extracts were administered to the experimental groups while Atorvastatin 10 mg/kg/p.o was given to standard control groups for 7 days. At 8th day blood sample was collected and serum samples were analyzed for biochemical parameters i.e. total serum cholesterol, serum triglycerides, HDL, LDL and VLDL level.
Results: %age yield of ethnolic extract was 17% and for aqueous extract it was 9%. 113±3.3, 105±5.7, 29±1.3, 102±2.0 and 27±1.1 mg/dl were level of serum cholesterol, triglycerides, HDL, LDL and VLDL respectively, observed in ethanolic extract treated rats while aqueous extract treated rats showed 111±2.0, 103± 2.2, 24±0.88, 102±1.1 and 27±0.95 mg/dl, respectively which were significantly (P < .001) different from disease controlled group. Results indicate significant reduction in the levels of total serum cholesterol, triglycerides, LDL and VLDL while level of HDL was significantly elevated in the experimental control groups.
Conclusion: All investigations indicated that Allium schoenoprasum dried leave extracts have potential to cause hypolipidemia.
Hyperlipedemia; Triton; HDL; VLDL; serum triglycerides.
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DOI : 10.9734/BJPR/2016/31804