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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 19, Issue.: 3

Original-research-article

Haptoglobin Phenotype and Soluble Transferrin Receptor among Tuberculosis

 

Philemond By1, H. T. Ahiboh2,3*, J. A. Sibli Koffi3, F. Koné4, H. Touré5, M. Traoré6, K. S. M. Domoua7, F. H. Yapi1 and D. Monnet3

1Laboratoire de Biochimie, Pharmacodynamie, UFR Bosciences, Université Félix Houphouet- Boigny, Côte d’Ivoire.

2Centre de Diagnostic et de Recherche sur le SIDA et Autres Maladies Infectieuses, CHU de Treichville, Abidjan, Côte d’Ivoire.

3Département de Biochimie et Biologie Moléculaire, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet – Boigny, Côte d’Ivoire.

4CeDReS Teaching Hospital of Treichville, BP V 3, Abidjan, Côte d’Ivoire.

5Centre National de Transfusion Sanguine, Abidjan, Côte d’Ivoire.

6Centre Anti-tuberculeux de Treichville Abidjan, 05 BP 1553 Abj 05, Abidjan, Côte d’Ivoire.

7Service de Pneumo-Phtisiologie, CHU de Treichville, Abidjan, Côte d’Ivoire.

Article Information
Editor(s):
(1) Fuhong SU, ICU Laboratory, Erasme Hospital, Free University Brussels, Brussels, Belgium.
Reviewers:
(1) Zeeshan Fatima, Amity University, India.
(2) Farid nakhoul, Padeh Poriya Hospital, Israel.
Complete Peer review History: http://www.sciencedomain.org/review-history/17220

Abstracts

Introduction: The antioxidant property of haptoglobin (Hp), variable according to the phenotypes, is associated with the pathogenesis of various diseases. Phenotype of haptoglobin is associated with iron metabolism, which is essential for the growth of Mycobacterium tuberculosis. A potential link between Hp phenotype and blood soluble transferrin receptor (sTfR) has not yet been established. This study aimed to determine the association between Hp phenotype and blood sTfR during tuberculosis (TB).

Materials and Methods: With a case-control study involving 70 TB patients and 70 healthy subjects were performed phenotyping of Hp by electrophoresis in polyacrylamide gel and determination of blood sTfR by immunoturbidimetry.

Results: The 3 major phenotypes of Hp were found: Hp1-1, Hp2-1, Hp2-2.  Hp2-2 phenotype was less common among TB patients (17.4% vs 82.6%, p < 0.001). The average rate of TB sTfR was lower than that of healthy subjects (27.5% vs 5.7%, p = 0,014).  In this group, blood sTfR of Hp2 subjects (Hp2-1 and Hp2-2) was lower than those of Hp1 subjects (p = 0.011). However, in healthy subjects, it appeared no association between Hp phenotype and blood sTfR.

Conclusion: the percentage of Hp2-2 was lower in patients with tuberculosis. Furthermore, Hp1-1 phenotype and Hp1 genotype were the most frequent among tuberculosis. In spite of M. tuberculosis infection, iron-dependent, no association was found between Hp and iron deficiency.

Keywords :

Phenotype; haptoglobin; soluble transferrin receptor; Mycobacterium tuberculosis; tuberculosis.

Full Article - PDF    Page 1-7

DOI : 10.9734/BJMMR/2017/30095

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