+91 8617752708

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 18, Issue.: 8

Case Report

A Rare Presentation of Signet Ring Squamous Cells in Ectocervical Squamous Epithelium Causing Diagnostic Difficulty in Reporting Cervical Intra-Epithelial Neoplasia


K. M. Rajyaguru1*, Ahmad Zakuan2 and S. I. Shahruddin3

1Department of Pathology, Faculty of Medicine and Defence Health, National Defence University, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia.

2Department of Pathology, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia.

3Department of Obstetrics and Gynecology, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia.

Article Information
(1) Kate S. Collison, Department of Cell Biology, King Faisal Specialist Hospital & Research Centre, Saudi Arabia.
(1) Gül Özcan, ─░stanbul University, Turkey.
(2) Luca Valerio Messa, University of Siena, Italy.
(3) Ajibola Idowu, Bowen University Teaching Hospital, Nigeria.
Complete Peer review History: http://www.sciencedomain.org/review-history/16817


We present a case of cervical intraepithelial neoplasia Grade II having many areas full of signet ring squamous (SRS) cells in 6-7 parabasal layers, covered by the layers of koilocytotic changes in outermost layers, with a brief review of the literature. Such presentation is extremely rare. A cone biopsy of the cervix was sent to the laboratory after pap smear preparation and small biopsy from the aceto-white area during colposcopy examination, which revealed few malignant cells. We grossed the specimen and selected the tissue from 1-12 o’clock positions and processed for paraffin blocks. H&E stained sections showed SRS cells at the majority of 1-12 positions. These SRS cells were negative for Alcian blue, Mucicarmine, Periodic acid–Schiff (PAS) and PAS-D stain and positive for cytokeratin. This presence of SRS cells has created difficulty in diagnosing the cervical intraepithelial neoplasia (CIN) case.

Keywords :

Signet ring squamous cell; cervix; squamous epithelium; intraepithelial neoplasia.

Full Article - PDF    Page 1-6

DOI : 10.9734/BJMMR/2016/29591

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,

+91 8617752708


Third Floor, 207 Regent Street
London, W1B 3HH,

+44 20-3031-1429