British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 1, Issue.: 3 (July-September)
Dermatitis Herpetiformis (DH) in Association with H. pylori Infection: Description of a Case Report
A. H. H. Bashir1,2*, M. A. El Tahir2 and A. M. El Hassan2 1Department of Dermatology and Venereology, Al Jawda Hospital, University of Juba, P. O. Box 11587, Khartoum, Sudan. 2Khartoum College of Medical Science, Jabir AbuEliz Diabetic Centre, Sudan.
A. H. H. Bashir1,2*, M. A. El Tahir2 and A. M. El Hassan2
1Department of Dermatology and Venereology, Al Jawda Hospital, University of Juba, P. O. Box 11587, Khartoum, Sudan.
2Khartoum College of Medical Science, Jabir AbuEliz Diabetic Centre, Sudan.
Dermatitis herpetiformis (DH) is an autoimmune blistering disorder associated with a gluten-sensitive enteropathy (GSE), and is generally accepted as a cutaneous manifestation of celiac disease and is characterized by grouped excoriations; erythematous, urticarial plaques; and papules with vesicles. We reported an interesting case of adult DH occurred in a 30 year old Sudanese young adult with chronic inflammatory bowel disease, presented with typical string of pearls in the face, trunk and extremities for 2 months duration. The case is diagnosed and confirmed as DH where histopathologically shows a sub-epidermal bulla with microabscess formation, sigmoidoscopy and H. pylori ELISA test were positive IgA.
Our case had an adult onset of presentation. Clinical features and histopathology are typical. It is associated of H. Pylori, although poorly responding to triple therapy (Doxycyclin 100 mg bid for 8 days, Cefixime 400 mg for 5 days and Rabeprazole as proton pump inhibitor (PPI) 20 mg for 28 days), but focusing as possible antigen was of paramount concern as possible causative antigen; as in this case all serological specific tests for Coeliac disease were negative.
The case was considered to be the second case of DH with CIBD due to H. Pylori been reported in Sudan.
Dermatitis Herpetiformis; Helicobacter pylori; Celiac disease;
Full Article - PDF Page 163-169
DOI : 10.9734/BJMMR/2011/364Review History Comments