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Annual Review & Research in Biology, ISSN: 2231-4776,Vol.: 3, Issue.: 4 (October-December)


Antisecretory Effects of Watermelon (Citrullus lanatus) Juice in Male Albino Rats


Francis S. Oluwole1, Morufu E. Balogun1 and Adedeji G. Temitope1*

1Department of Physiology, College of Medicine, University of Ibadan, Oyo State. Nigeria.

Article Information


(1) Prof. Paula I. Moreira, Institute of Physiology, Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.

(2) Dr. Clovis Andrade Neves, Federal University of Viçosa, Brazil.

(3) Prof. George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.


(1) Manish A. Rachchh, S. J. Thakkar Pharmacy College, India.

(2) Anonymous.

(3) Mohammed Asad, Shaqra Universtiy, Saudi Arabia.

Complete Peer review History: http://www.sciencedomain.org/review-history/1459


Aims: To evaluate the effects of the juice of Citrullus lanatus (watermelon) on gastric acid secretion and pH in Indomethacin-induced ulceration in male albino rats.
Study Design: The experiment was divided into two studies. Under each study, four groups of rats were pre-treated with distilled water (control), 25% watermelon, 50% watermelon and 100% watermelon juice respectively for 30 days.
Place and Duration of Study: Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria, between June, 2011 and July, 2012.
Methodology: Sixty-four animals in total were used for the experiment. The animals were divided into two experimental studies: Study I contained thirty-two rats which were used for the study on ulcerogenesis. Study II also contained thirty-two rats which were used for the study on gastric acid secretion. Each of the experimental studies was further divided into four groups in accordance with the study design.
Results: Rats pre-treated with Citrullus lanatus juice exhibited significant dose-dependent reduction of gastric lesions formation (P<0.05). Also, ulcerogenesis in the pretreated groups was significantly lower than that observed with the control (P<0.05).
Conclusion: The results suggest that Citrullus lanatus (watermelon) juice has a significant gastroprotective effect in Indomethacin-induced gastric ulceration. One of the mechanisms by which this protective effect is carried out is by its inhibition of gastric acid secretion.

Keywords :

Gastric ulcer; watermelon; Citrullus lanatus; gastric acid secretion.

Full Article - PDF    Page 358-366

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