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British Journal of Medicine and Medical Research

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 3, Issue.: 4 (October-December)


Dietary Pattern Low in Fruits Explains Variations in Inflammation and in Biomarkers of Cardiovascular Disease in Latinos Diagnosed with Type-2 Diabetes


Mariana C. Calle1,2,3*, Sonia Vega-López 3,4, Sofia Segura-Pérez 3,5, Rafael Pérez-Escamilla 2,3,6 and Maria Luz Fernandez 2,3

1Department of Health Sciences, Worcester State University, USA.
2Department of Nutritional Sciences, University of Connecticut, USA.
3Connecticut NIH EXPORT Center for Eliminating Health Disparities among Latinos, USA.
4Arizona State University, USA.
5Hispanic Health Council, USA.
6School of Public Health, Yale University, USA.


Article Information


(1) Salomone Di Saverio, Emergency Surgery Unit, Department of General and Transplant Surgery, S. Orsola Malpighi University Hospital, Bologna, Italy.


(1) Anonymous.

(2) Eman M. Alissa, King Abdulaziz University, Saudi Arabia.

Complete Peer review History:




Aims: 1) To identify a dietary pattern associated with plasma interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα) and monocyte chemotactic protein-1 (MCP-1) in Latinos diagnosed with T2D. 2) To examine whether the “pro-inflammation” dietary pattern obtained is associated with additional cardiovascular disease risk in this Latino population.
Methodology: Reduced rank regression was used to determine the cross-sectional relationship between food patterns and plasma inflammatory biomarkers in Latinos (26 men/77 women, 32-76 y) diagnosed with type-2 diabetes (T2D). Reduced rank regression was used to create 3 dietary patterns from 33 food groups. We included IL-6, TNFα, and MCP-1 as response variables to derive 3 dietary patterns.
Study Design: Cross-sectional.
Place and Duration of Study: University of Connecticut, Hartford Hospital, and the Hispanic Health Council, between January 2010 and May 2011.
Results: The first dietary pattern characterized by low intake of fruits and yellow vegetables and high intake of refined grains and sugar-free beverages explained the largest proportion of variance in inflammation markers. After adjusting for confounding factors including energy intake, statin treatment, waist circumference, glycosylated hemoglobin and blood pressure, IL-6 (P< 0.0001) and TNFα (P =0.0004) were positively associated with the first dietary pattern. Food groups that were negatively associated with inflammation markers were fruits and dark yellow vegetables, explaining 10.2% and 4.6% of the variance, respectively. This dietary pattern was also significantly associated with higher number of large VLDL particles (P < 0.05) after adjusting for WC, statins use and systolic blood pressure as well as higher concentrations of apolipoprotein A-2 after adjusting for WC and energy (P< 0.05).
Conclusion: This dietary pattern may increase heart disease risk in this already challenged population.


Keywords :

Dietary pattern; latinos; type-2 diabetes; cardiovascular disease risk; TNFα; inflammation.


Full Article - PDF    Page 1558-1573    Article Metrics


DOI : 10.9734/BJMMR/2013/4248

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