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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 14, Issue.: 4

Original-research-article

Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease

 

Javier Olazarán1,2*, Pablo García-Polo1, Daniel García-Frank1, Alicia Quirós1, Juan Antonio Hernández-Tamames1, Carmen Acedo3, Juan Álvarez-Linera1 and Ana Frank3

1Alzheimer Disease Research Unit, Alzheimer Center Reina Sofía Foundation - CIEN Foundation, Carlos III Institute of Health, Madrid, Spain.

2Gregorio Marañón University Hospital, Madrid, Spain.

3La Paz University Hospital, Madrid, Spain.

Article Information
Editor(s):
(1) Xin-an Liu, Neuroscience Department, the Scripps Research Institute, Scripps, Florida, USA.
(2) Jingli Xu, College of Pharmacy, University of New Mexico, USA.
Reviewers:
(1) Hazem Mohammed Ebraheem Shaheen, Damanhour University, Egypt.
(2) D. Sivaraman, Sathyabama University, Tamilnadu, India.
Complete Peer review History: http://sciencedomain.org/review-history/13594

Abstracts

Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD).

Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package.

Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected).

Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.

Keywords :

Alzheimer’s disease; depression; magnetic resonance imaging; structural correlates.

Full Article - PDF    Page 1-10

DOI : 10.9734/BJMMR/2016/24034

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