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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 14, Issue.: 4


Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease


Javier Olazarán1,2*, Pablo García-Polo1, Daniel García-Frank1, Alicia Quirós1, Juan Antonio Hernández-Tamames1, Carmen Acedo3, Juan Álvarez-Linera1 and Ana Frank3

1Alzheimer Disease Research Unit, Alzheimer Center Reina Sofía Foundation - CIEN Foundation, Carlos III Institute of Health, Madrid, Spain.

2Gregorio Marañón University Hospital, Madrid, Spain.

3La Paz University Hospital, Madrid, Spain.

Article Information
(1) Xin-an Liu, Neuroscience Department, the Scripps Research Institute, Scripps, Florida, USA.
(2) Jingli Xu, College of Pharmacy, University of New Mexico, USA.
(1) Hazem Mohammed Ebraheem Shaheen, Damanhour University, Egypt.
(2) D. Sivaraman, Sathyabama University, Tamilnadu, India.
Complete Peer review History: http://sciencedomain.org/review-history/13594


Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD).

Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package.

Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected).

Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.

Keywords :

Alzheimer’s disease; depression; magnetic resonance imaging; structural correlates.

Full Article - PDF    Page 1-10

DOI : 10.9734/BJMMR/2016/24034

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