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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 13, Issue.: 10


Anxiety Sensitivity and Comorbid Psychiatric Symptoms over the Course of Cognitive Behavioural Therapy for Panic Disorder


Sei Ogawa1*, Masaki Kondo1, Keiko Ino1, Toshitaka Ii1, Risa Imai1, Toshi A. Furukawa2 and Tatsuo Akechi1

1Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.

2Department of Health Promotion and Human Behavior, Kyoto University, Graduate School of Medicine / School of Public Health, Kyoto, Japan.

Article Information


(1) Xin-an Liu, Neuroscience Department, the Scripps Research Institute, Scripps, Florida, USA.


(1) Anonymous, Spain.

(2) Diana C. Tapia-Pancardo, National Autonomous University of Mexico, Mexico.

Complete Peer review History: http://sciencedomain.org/review-history/13288


Aims: Anxiety sensitivity (AS) might be the core vulnerability in the pathogenesis of AXIS I diagnosis and might be the important transdiagnostic target for the interventions for comorbid psychiatric symptoms in panic disorder (PD). This study aimed to examine the relationship of changes in the three factors of AS and changes in comorbid psychiatric symptoms over the course of cognitive behavioural therapy (CBT) for PD.

Methodology: One hundred eighteen patients with PD were treated with manualized group CBT. Using multiple regression analysis, we examined the associations between the changes in subscales of Symptom Checklist-90 Revised (SCL-90-R) and the changes in factors of the Anxiety Sensitivity Index (ASI) involving Physical Concerns, Mental Incapacitation Concerns, and Social Concerns over the course CBT.

Results: Reductions in Mental Incapacitation Concerns of ASI were related to decreases in 8 SCL-90-R scales, including Obsessive-Compulsive, Interpersonal Sensitivity, Depression, Hostility, Phobic Anxiety, Paranoid Ideation, Psychoticism, and GSI. Reductions in Physical Concerns were related to decreases in 5 SCL-90-R scales, including Somatization, Depression, Anxiety, Phobic Anxiety, and GSI.

Discussion: The present study suggests that reductions in AS, especially mental and physical dimensions, predict comorbid psychiatric symptoms reduction over the course of CBT for PD.

Keywords :

Panic disorder; anxiety sensitivity; cognitive behavioural therapy; comorbid psychiatric symptoms.

Full Article - PDF    Page 1-7

DOI : 10.9734/BJMMR/2016/23979

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