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British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 3, Issue.: 3 (July-September)

Original-research-article

Regulated Effects of Capsicum frutescens Supplemented Diet (C.F.S.D) on Fasting Blood Glucose Level, Biochemical Parameters and Body Weight in Alloxan Induced Diabetic Wistar Rats

 

Ojieh E. Anthony1*, Adegor C. Ese1 and Ewhre O. Lawrence2

1Department of Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria.
2Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria.

Article Information

Editor(s):

(1) Xiang-Chun Shen, Research Division of Pharmacology, Guiyang Medical University, China.

Reviewers:

(1) Shanti Bhushan Mishra, United Institute of Pharmacy, India.

(2) Robert L. Jarret, USA.

(3) Anonymous.

Complete Peer review History: http://www.sciencedomain.org/review-history/1325

Abstracts

Aim of the Study: This study investigates the effects of Capsicum frutescens supplemented diet (C.F.S.D) on fasting blood glucose level, biochemical parameters and body weight in alloxan induced diabetic Wistar rats.
Experimental Design: 130 – 150g healthy forty male Wistar rats were divided into four groups as following; Group 1 served as a normal control and received normal feed-. Group 2 (Diabetic control) received normal feed-. Group 3 (Diabetic test 1) received normal feed + 1g Capsicum frutescens.-. Group 4 (Diabetic test 2) received normal feed + 2g Capsicum frutescens.
Place and Duration of Study: This study was carried out in the department of Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka and the feeding lasted for three weeks. At the end of the experiments, the animals were sacrificed, blood samples were collected and then the serum was further subjected to biochemical analysis using biochemical analyzer (Reflotron Plus).
Results: AST, ALT, ALP, GGT, Creatinine, Uric acid, total cholesterol and fasting blood sugar level in serum were increased however the high density lipoprotein cholesterol (HDL-c) of serum was decreased in diabetic control (group 2), compared with non-diabetic control (group 1). The administered Capsicum frutescens in the diet at 1g and 2g doses significantly reduced the fasting blood glucose level as well as the serum level of AST, ALT, ALP, GGT, Creatinine, Uric acid, total cholesterol, compared with diabetic control. Serum HDL was also significantly increased when compared with diabetic control P<0.05. Decrease in body weight in diabetic control group and increased in body weight of 1gand 2g Capsicum frutescens supplemented diet groups were also observed.
Conclusion: The observed improvement in the biochemical parameters, blood glucose levels and body weight of alloxan induced diabetic Wistar rats by 1g and 2g Capsicum frutescens supplemented diet suggests Capsicum frutescens to possess, cardio-protective and anti-diabetic properties.
Recommendation: The incorporation of Capsicum frutescens as spice in the diet of individuals who are diabetic, hypertensive and obese, is worthy of recommendation.

Keywords :

Capsicum frutescens; fasting blood glucose; liver enzymes; capsaicin; thermogenesis.

Full Article - PDF    Page 496-507

DOI : 10.9734/BJPR/2013/3256

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