+91 8617752708

British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 3, Issue.: 3 (July-September)

Original-research-article

Stability Indicating Simultaneous Equation Method for Determination of Domperidone and (S)-Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer

 

Sunil Singh1*, Jyoti Rai1, Inamullah1, Nisha Choudhary1, Hemendra Gautam2, Surabhi Sharma3, Ajit Kumar Yadav4, Vipin Kumar Agrawal4 and Shashank Chaturvedi4

1Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly-243 123, Uttar Pradesh, India.
2Department of Pharmacology, Invertis Institute of Pharmacy, Invertis University, Bareilly-243 123, Uttar Pradesh, India.
3Department of Pharmacognosy, Invertis Institute of Pharmacy, Invertis University, Bareilly-243 123, Uttar Pradesh, India.
4Department of Pharmaceutics, Invertis Institute of Pharmacy, Invertis University, Bareilly-243 123, Uttar Pradesh, India.

Article Information

Editor(s):

(1) Dongdong Wang, Department of Pharmacogonosy, West China College of Pharmacy, Sichuan University, China.

(2) Vasudevan Mani, Universiti Teknologi MARA (UiTM), Selangor, Malaysia.

(3) Ke-He Ruan, Director of the Center for Experimental Therapeutics and Pharmacoinformatics (CETP), Professor of Medicinal Chemistry & Pharmacology, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, USA.

Reviewers:

(1) Hérida Regina Nunes Salgado, Univ Estadual Paulista, Brazil.

(2) Anonymous.

Complete Peer review History: http://www.sciencedomain.org/review-history/1311

Abstracts

Aims: Stability indicating simultaneous equation method for determination of Domperidone and Esomeprazole Magnesium in capsule dosage form using UV-Spectrophotometry.
Study Design: A new simultaneous equation method was developed and validated for the determination of esomeprazole magnesium and domperidone in capsule dosage form.
Place and Duration of Study: Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh during July 2012 to June 2013.
Methodology: Simultaneous equation method was performed for estimation of dosage form and degradants.
Results: The maximum wavelength (λmax) was found to be 299 nm for esomeprazole magnesium and 287 nm for domperidone. The linearity range was found to be 1-6 µg ml-1 (r2= 0.998) and 5-30 µg ml-1 (r2= 0.999) for esomeprazole magnesium and domperidone, respectively. The value of limit of detection and limit of quantification was 0.116 and 0.386 µgml-1 for esomeprazole magnesium and 0.657 and 2.18 µgml-1 for domperidone, respectively. Forced degradations were carried out under acid, base, thermal, photolytic and oxidative stress conditions. The method was satisfactorily validated as per the ICH guideline.
Conclusion: This study shows that the proposed spectrophotometric method is useful for the routine determination of esomeprazole magnesium and domperidone in its combined pharmaceutical dosage form.

Keywords :

Esomeprazole magnesium; domperidone; simultaneous equation; forced degradation studies; validation.

Full Article - PDF    Page 435-445

DOI : 10.9734/BJPR/2013/3197

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,
India

+91 8617752708

 

Third Floor, 207 Regent Street
London, W1B 3HH,
UK

+44 20-3031-1429