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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 12, Issue.: 10


Outcome of Adapalene and Isotretinoin in the Treatment of Acne Vulgaris


Sami Fatehi Abdalla1*, Nadia Taha2 and Bakri Alagraa3

1Department of Dermatology and Physiology, International University of Africa, Sudan.

2Clinical Dermatology, Khartoum Dermatology Hospital, Sudan.

3Department of Dermatology, University of Bakht El-Rhoda, Sudan.

Article Information


(1) Thomas I. Nathaniel, University of South Carolina, School of Medicine-Greenville, Greenville, SC 29605, USA.


(1) Mutlu Çayırlı, Mevki Military Hospital, Turkey.

(2) Anonymous, Shin Kong Wu Hou-Su Memorial Hospital, Taiwan.

(3) Roberto Martínez Beamonte, Universidad de Zaragoza, Spain.

Complete Peer review History: http://sciencedomain.org/review-history/12537


Topical application of Isotretinoin and Adapalene has proved effective in treating acne vulgaris. Both drugs demonstrate therapeutic advantages and less irritancy over tretinoin, the most widely used treatment for acne. The objective of this study was to compare the efficacy and tolerability of Adapalene cream 0.1% and Isotretinoin cream 0·05% in the treatment of acne vulgaris.

Hundred patients were enrolled and were instructed to apply Adapalene cream 0.1% (50 patients) or Isotretinoin cream 0.05% (50 patients) once daily over a 6-week treatment period. Efficacy determination included non-inflammatory and inflammatory lesions count by the investigator and global evaluation of improvement.

Cutaneous tolerance was assessed by determining erythema, scaling, burning and pruritus. Adapalene and Isotretinoin creams were highly effective in treating acne vulgaris. However Adapalene was found significantly more effective than Isotretinoin. Adapalene  has faster onset of action of, which reflects on patients psychologically in term of improvements, comforts and good appearance. Significantly lower skin irritation was noted with Adapalene , indicating that Adapalene  may begin a new era of treatment with low-irritant retinoids. It seems that, Adapalene treatment is a good choice for topical treatment of acne vulgaris with less side effects and high efficacy. Adapalene should be described as first line for treatment of acne vulgaris.

Keywords :

Acne vulgaris; Adapalene; Isotretinoin; outcome.

Full Article - PDF    Page 1-9

DOI : 10.9734/BJMMR/2016/22385

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