+91 8617752708

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 12, Issue.: 4


Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies


R. A. Vhriterhire1*, J. A. Ngbea1, B. A. Ojo1, O. O. Jegede2, A. N. Manasseh3, M. D. Ayuba3 and B. M. Mandong3

1Department of Histopathology, College of Health Sciences, Benue State University, Makurdi, Nigeria.

2Department of Morbid Anatomy, College of Health Sciences, Bingham University, Jos, Nigeria.

3Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria.

Article Information


(1) Arun Kumar Nalla, College of Medicine, University of Illinois, Peoria, IL, USA.


(1) Lorenzo Dioscoridi, University of Florence, Italy.

(2) Rocio del Pilar Lopez Panqueva, University of Los Andes, Bogota, Colombia.

(3) Amal Ahmed Mohamed, National Hepatology and Tropical Medicine Research Institute, Egypt.

(4) Jose Francisco de Sales Chagas, Catholic University of Campinas, Brazil.

Complete Peer review History: http://sciencedomain.org/review-history/12165


Introduction: Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide and a greater burden of this disease is born by the hepatitis B virus (HBV) endemic and resource deficient sub-Sahara Africa. This investigation was carried out to determine the pattern of hepatocellular carcinoma sub-types in north-central Nigeria.

Materials and Methods: Archival formalin fixed and paraffin embedded 374 liver biopsy specimen blocks were obtained, sectioned, re-stained and examined histologically. Classification of primary liver cancers was done according to standard World Health Organisation criteria. 

Results: Chronic HBV infection was found in 219 (58.6%) and cirrhosis in 29 (7.8%) cases. HCC occurred in 76 (20.3%) cases with background cirrhosis in 18 (23.7%) of the HCC. The HCC subtypes found were the trabecular 54 (71.1%), acinar 10 (13.2%) and mixed trabecular and acinar 6 (7.9%), clear cell 5 (6.6%) and fibrolamellar 1 (1.3%) respectively.

Conclusion: HCC is the most common histologically diagnosed primary liver cell carcinoma with the trabecular subtype as the predominant variant in Nigeria, followed by the pseudoglandular and the mixed types.

Keywords :

Liver; liver biopsy; hepatocellular carcinoma; hepatocellular carcinoma sub-types.

Full Article - PDF    Page 1-8

DOI : 10.9734/BJMMR/2016/21772

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,

+91 8617752708


Third Floor, 207 Regent Street
London, W1B 3HH,

+44 20-3031-1429