British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 3, Issue.: 4 (October-December)
Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents
Ambika P. Ashraf1*, Jessica Alvarez2, Carrie Huisingh3, Krista Casazza4 and Barbara Gower4 1Department of Pediatrics/Division of Pediatric Endocrinology and Metabolism, The Children's Hospital, University of Alabama Birmingham, Birmingham, USA.
2Division of Endocrinology, Emory University School of Medicine, Atlanta, USA.
3Center for Clinical and Translational Sciences, University of Alabama at Birmingham, USA.
4Department of Nutrition Sciences, University of Alabama Birmingham, Birmingham, USA.
Ambika P. Ashraf1*, Jessica Alvarez2, Carrie Huisingh3, Krista Casazza4 and Barbara Gower4
1Department of Pediatrics/Division of Pediatric Endocrinology and Metabolism, The Children's Hospital, University of Alabama Birmingham, Birmingham, USA.
(1) Xiaofeng Ren, College of Veterinary Medicine, Northeast Agricultural University, China.
(2) K. S. Collison, Diabetes Research Unit, Department of Cell Biology, King Faisal Specialist Hospital & Research Centre, POB 3354, Riyadh 11211, Saudi Arabia.
(1) John M. Pettifor, University of the Witwatersrand, South Africa.
Complete Peer review History:http://www.sciencedomain.org/review-history/1136
Background: Puberty is a developmental stage of increased insulin resistance that also is a critical period for bone mass accrual. Historically, African Americans (AA) have lesser risk for osteoporotic fractures compared to European Americans (EA). AA also have higher incidence of insulin resistance. The possibility that bone health and insulin secretion or concentrations are linked has not been investigated.
Aims: We aimed to examine the associations of bone mineral density (BMD) and bone mineral apparent density (BMAD) with insulin sensitivity and secretion in healthy adolescent girls and healthy female adults and to evaluate ethnic differences in these associations.
Study Design: Observational cohort design.
Place and Duration of the Study: University of Alabama at Birmingham, between January 2010 and September 2011.
Methodology: Healthy, female, non-smoking adolescents and young adults (14-55 years) were enrolled in this observational cohort study.
Results: Adolescents had significantly higher fasting insulin (P=0.0002), insulin area under the curve [AUC] (P= 0.0004) and lower insulin sensitivity (P=0.0005) compared to adults. Among adolescents, AA race was significantly associated with BMD (β=0.086, P=0.01) and BMAD (β=0.0075, P=0.002); however, adjusting for insulin AUC explained this difference. Insulin AUC (β=0.0006, P=0.029) and fasting insulin (β=0.0005, P=0.01) were positively associated with BMAD only in AA adolescents. Insulin AUC and fasting insulin were not significant predictors of BMD for adults.
Conclusion: The higher insulin concentration among AA adolescents is associated with increased BMD and higher BMAD.
Bone mineral density; insulin secretion; ethnic differences; bone mass.
Full Article - PDF Page 1050-1061
DOI : 10.9734/BJMMR/2013/2720Review History Comments