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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 10, Issue.: 8


Activity of Autonomic Nervous System, Energy Expenditure and Assessment of Oxidative Stress in Menopause-women Using Hormone Replacement Therapy


Giovanni Messina1,2*, Vincenzo De Luca1, Andrea Viggiano3, Domenico Tafuri4, Antonietta Messina1, Fiorenzo Moscatelli2,5, Antonio Ivano Triggiani2, Giuseppe Cibelli2, Anna Valenzano2, Sergio Chieffi1 and Marcellino Monda1

1Department of Experimental Medicine, Section of Human Physiology and Clinical Dietetic Service, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy.

2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

3Faculty of Medicine, University of Salerno, Salerno, Italy.

4Faculty of Motor Sciences, University of Naples “Parthenope”, Naples, Italy.

5Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy.

Article Information


(1) Dongbao Chen , Division of Maternal-Fetal Medicine, Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of California Irvine, Irvine, CA 92697, USA.

(2) Vijayalakshmi I. Balekundri, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India.


(1) Pietro Scicchitano, Hospital “F. Perinei”, Italy.

(2) A. Papazafiropoulou, Tzaneio General Hospital of Piraeus, Greece.

(3) Jaspinder Kaur, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India.

Complete Peer review History: http://sciencedomain.org/review-history/11151


Aims: Menopause is a period of significant physiological change that may be associated with increased body weight and obesity-related diseases. Many studies have been carried out to determine influences of estrogen depletion, resting energy expenditure (REE) decline and aging during menopause-related obesity.

Methodology: In the present experiment, REE, body composition, activity of the autonomic nervous system, oxidative stress and food intake were measured in three groups of women: pre-menopause (n=40), post-menopause with hormone-replacement therapy (HRT) (n=40) and post-menopause without HRT (n=40).

Results: In post-menopause women with HRT a significant increase was found in: 1) the sympathetic activity, measured by the power spectral analysis of the heart rate variability; 2) REE, measured by indirect calorimetry; 3) oxidative stress, measured by Free Radical Analytical System 4 (Fras-4) compared to the value of the other two, while fat mass, measured by Body Impedance Analysis (BIA), was reduced in favor of a recovery of free fat mass.

Conclusion: The study emphasizes the important changes due to HRT on various components influencing body weight in menopause-women.

Keywords :

Hormone-replacement therapy; resting energy expenditure; autonomic nervous system; body composition; assessment of oxidative stress.

Full Article - PDF    Page 1-13

DOI : 10.9734/BJMMR/2015/18877

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