+91 8617752708

British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 3, Issue.: 2 (April-June)


Combined Oral Arginine and Monosodium Glutamate Exposure Induces Adverse Response on the Prostate Function and Testis Histology of Rats


Egbuonu A. C. Cemaluk1*, Ejikeme P. Madus2, L. U. S. Ezeanyika1 and O. Obidoa1

1Nutrition and Toxicological Biochemistry Unit, Department of Biochemistry, University of Nigeria Nsukka, Nigeria.
2Industrial Chemistry Unit, Department of Pure and Industrial Chemistry, University of Nigeria Nsukka, Nigeria.

Article Information


(1) Othman Ghribi, Department of Pharmacology, Physiology & Therapeutics, University of North Dakota, USA.

(2) Ke-He Ruan, Director of the Center for Experimental Therapeutics and Pharmacoinformatics (CETP), Professor of Medicinal Chemistry & Pharmacology, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, USA.


(1) Dolores D. Mruk, USA.

(2) Shengrong Shen, Zhejiang University, China.

(3) Wei Wang, The People's Hospital of Guangxi Zhuang Autonomous Region, China.

(4) Anonymous.

Complete Peer review History:http://www.sciencedomain.org/review-history/1038


Aims: This study investigated the effect of exposure to arginine (ARG) and glutamate (GLU), or its variant, monosodium glutamate (MSG) on the prostate function and testis histology of rats.
Study Design: Exposure to either ARG, GLU, monosodium glutamate (MSG), ARG plus GLU or ARG plus MSG was per oral for 4 consecutive weeks. On the last day of the experiment, rats were food-deprived for 15 h before collecting their blood and testis samples.
Place and Duration of Study: Department of Biochemistry and Department of Veterinary Pathology, University of Nigeria Nsukka, Nigeria, between June 2005 and June 2006.
Methodology: Total and prostatic acid phosphatase activities in serum were determined by the method of Walter and Schutt. Testis sections were stained and mounted using haematoxylin and eosin (H&E), for histology.
Results: On comparison with control, the results showed that ARG, GLU, or arginine together with monosodium glutamate (ARG+MSG) induced a significant (p<0.05 and p<0.01) elevation whereas, ARG+GLU caused a reduction (p<0.05 and p<0.01), in serum total acid phosphatase (TAP) and prostatic acid phosphatase (PAP) activities. MSG-induced reduction in TAP activity (20.76 ± 0.18 I.U/L), however, was not statistically significant (p>0.05 and p>0.01). Histological examination of the testis sections revealed varying degree of degeneration characterized by necrosis in ARG+GLU and ARG+MSG groups relative to control and ARG, GLU or MSG groups.
Conclusion: Results may indicate variable treatment related adverse effect on the prostate function and the testis histology of the rats. The possible effect, however, appeared higher following concomitant exposure to ARG and MSG. Thus, caution should be exercised in the simultaneous ingestion of arginine and monosodium glutamate in animals. Further work however, is required to address some shortcomings (including small sample size) of this study to validate reliability.

Keywords :

Testis histomorphology; arginine; glutamate. prostatic acid phosphatase; prostate.

Full Article - PDF    Page 247-258

DOI : 10.9734/BJPR/2013/2172

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,

+91 8617752708


Third Floor, 207 Regent Street
London, W1B 3HH,

+44 20-3031-1429