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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 9, Issue.: 10


Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force


Jie Feng1, Yang Xu1, Li Xu1, Qiuyue Guan2, Zheng Wang1, Ding Bai1 and Xianglong Han1*

1Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.

2Department of Geriatrics, People’s Hospital of Sichuan Province, Chengdu, P.R. China.

Article Information
(1) Hai Ming Wong, The University of Hong Kong, 2/F, Prince Philip Dental Hospital, Hong Kong.
(1) Angelo Troedhan, Faculty of Dentistry, Health Science University, Vientiane, Laos.
(2) Anonymous, USA.
(3) Deepak Kadeli, Department of Internal Medicine, BLDE University, India.
Complete Peer review History: http://sciencedomain.org/review-history/10227


Integrins are mechanoreceptors and mediate mechanotransduction by transferring forces into focal adhesions. Osteoclastogenesis starts with adhesion to the bone matrix, leading to cytoskeleton reorganization that is important for osteoclast polarization and migration. However, there are several signaling pathways mediating this process, and integrins have been shown to be important signaling molecules participating osteoclastogenesis. Particularly, integrins have played an important role in both force transduction and osteoclastogenesis. This paper reviewed the findings on the relationship between integrins and reorganization of osteoclast cytoskeleton under orthodontic force.

Keywords :

Orthodontic force; integrin; osteoclastogenesis; cytoskeleton.

Full Article - PDF    Page 1-8

DOI : 10.9734/BJMMR/2015/19544

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